2. Anti-infection Cell Cycle/DNA Damage
  3. Antibiotic Bacterial DNA/RNA Synthesis
  4. Sarecycline

Sarecycline 是一种口服有效的窄谱四环素衍生物类抗生素。Sarecycline 具有抗炎活性。Sarecycline 能够抑制革兰氏阳性细菌和多种痤疮角质杆菌的活性。Sarecycline 干扰 tRNA 调节并将 mRNA 与 70S 核糖体结合。Sarecycline 能够用于中重度痤疮的研究。

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Sarecycline Chemical Structure

Sarecycline Chemical Structure

CAS No. : 1035654-66-0

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Sarecycline 的其他形式现货产品:

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Sarecycline 相关抗体

Top Publications Citing Use of Products

    Sarecycline purchased from MCE. Usage Cited in: Microbiol Spectr. 2022 Dec 8;e0323822.  [Abstract]

    The MIC distributions of Sarecycline against 43 M. fortuitum isolates. The y axis shows the number of strains with each MIC value, with the specific numbers shown above the bars.

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    Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Sarecycline is an orally effective narrow-spectrum tetracycline derivative antibiotic. Sarecycline has anti-inflammatory activity. Sarecycline inhibits the activity of Gram-positive bacteria and several types of keratobacterium acnes. Sarecycline interferes with tRNA accommodation and tethers mRNA to the 70S ribosome. Sarecycline can be used to study moderate to severe acne[1][2][3][4][5][6].

    IC50 & Target

    Tetracycline

     

    体外研究
    (In Vitro)

    Sarecycline 抑制 55 株临床分离的痤疮棒状杆菌，其 MIC 值为 0.5~16 µg/ml; MIC50 为 0.5 µg/ml, MIC90 为 4µg/ml[1]。
    Sarecycline 对大环内酯耐药的生物体有活性[1]。
    Sarecycline hydrochloride对肠道需氧革兰氏阴性菌的活性最小[2]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Sarecycline 相关抗体:
    体内研究
    (In Vivo)

    Sarecycline hydrochloride (0.33-9 mg /kg; 静脉注射) 在小鼠中性粒细胞减少的大腿感染模型中显示出对金黄色葡萄球菌的有效活性[1]。
    Sarecycline 在全身 (腹腔) 感染的 CD-1 小鼠模型中能够抑制金黄色葡萄糖球菌 (PD50=0.25 mg/kg)，但在最高剂量 (>40 mg/kg) 下对大肠杆菌抑制的效果不明显[6]。
    Sarecycline (1-150mg/kg; 腹腔注射; 单剂量) 在 Sprague Dawley 大鼠模型中具有抗炎活性[6]。

    MCE has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Carrageenan-induced footpad edema male Sprague Dawley rats model[6]
    Dosage: 1 mg/kg, 5 mg/kg ,10 mg/kg, 25 mg/kg, 50 mg/kg, 75 mg/kg,100 mg/kg, 150 mg/kg
    Administration: Intraperitoneal injection (i.p.); Single dose. Before a subplantar injection of sterile 1 mg/0.1 mL carrageenan solution in the right hind paw.
    Result: Reduced inflammation to 55.7% and 53.1%, respectively, at doses of 75 mg/kg and 100 mg/kg compared to baseline.
    Animal Model: Carrageenan-induced footpad edema male Sprague Dawley rats model[6]
    Dosage: 0.33, 1, 3, or 9 mg/kg
    Administration: Intravenously
    Result: Achieved a 2-log10 reduction in the bacterial burden in the thigh at a dose comparable to that of doxycycline, with ED50s of 8.23 and 8.32 mg/kg, respectively.
    Clinical Trial
    分子量

    487.50

    Formula

    C24H29N3O8
    CAS 号
    运输条件

    Room temperature in continental US; may vary elsewhere.
    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.
    纯度 & 产品资料
    参考文献

    Sarecycline 相关分类

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Sarecycline1035654-66-0P-005672P005672P 005672AntibioticBacterialDNA/RNA SynthesisAcneInflammationTetracyclinetetracycline-classbacteriaanti-inflammatory70SribosomeInhibitorinhibitorinhibit

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