2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. SD-6

SD-6 是一种具有口服活性的 hAChE 和 hBChE 抑制剂，IC50 值分别为 0.907 µM 和 1.579 µM。SD-6 具有优良的血脑屏障 (BBB) 渗透性且无神经毒性，可用于阿尔茨海默病研究。

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SD-6 Chemical Structure

SD-6 Chemical Structure

CAS No. : 744206-31-3

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SD-6 相关抗体

Top Publications Citing Use of Products

查看 Cholinesterase (ChE) 亚型特异性产品:

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AChE BChE

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SD-6 is an orally active inhibitor of hAChE and hBChE with IC50 values of 0.907 µM and 1.579 µM, respectively. SD-6 has excellent blood-brain barrier (BBB) permeability and no neurotoxicity, which can be used for research on Alzheimer's disease[1].

IC50 & Target[1]

hAChE

0.907 μM (IC50)

hBCHE

1.579 μM (IC50)

体外研究
(In Vitro)

SD-6 (5-80 µM；24 h) 在 SH-SY5Y 细胞中具有神经保护作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SD-6 相关抗体:

Cell Viability Assay[1]

Cell Line: SH-SY5Y cells.
Concentration: 5, 10, 20, 40 or 80 µM.
Incubation Time: 24 h.
Result: Exhibited toxicity to differentiated SH-SY5Y cell lines and has a protective effect on undifferentiated SH-SY5Y cell lines.
体内研究
(In Vivo)

SD-6 (100、300 和 500 mg/kg；口服；单剂量) 对未怀孕的雌性 Wistar 大鼠没有毒性作用[1]。
SD-6 (2.5、5 和 10 mg/kg；口服；一天 3 次，持续 7 天) 改善了东莨菪碱 (HY-N0296) 诱导的雄性 Wistar 大鼠认知和记忆缺陷[1]。
SD-6 (2.5、5 和 10 mg/kg；口服；单剂量) 显著改善了大鼠中东莨菪碱诱导的异常，促进生化指标正常化[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 10–11 weeks nonpregnant female Wistar rats (220–280 g)[1].
Dosage: 100, 300 and 500 mg/kg.
Administration: Oral gavage; single dose.
Result: Showed safety and tolerability.
Animal Model: 10–11 weeks male Wistar rats (220–280 g)[1].
Dosage: 2.5、5、10 mg/kg.
Administration: Oral gavage; 3 times a day for 7 days or single dose.
Result: Had the function of repairing cognitive and memory deficits.
Reduced the level of AChE and malonaldehyde (MDA), increased the level of acetylcholine, superoxide dismutase (SOD), glutathione (GSH) and catalase.
分子量

366.48

Formula

C20H22N4OS
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SD-6 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SD-6744206-31-3SD6SD 6Cholinesterase (ChE)Wistar ratsScopolamineSH-SY5Y cellsInhibitorinhibitorinhibit

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