2. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation Apoptosis
  3. Epoxide Hydrolase NF-κB Interleukin Related TNF Receptor
  4. sEH-IN-21

sEH-IN-21 是一种口服有效的 sEH 抑制剂，对 hsEH 和 msEH 的 IC5050 值均为 0.1 nM。sEH-IN-21 显著抑制 NF-κB 信号通路。sEH-IN-21 显示出很强的抗炎活性，降低了 IL-6 和 TNF-α 的释放，并保持了肠道屏障的完整性。sEH-IN-21 可用于炎症性肠炎 (IBD) 的研究。

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sEH-IN-21 Chemical Structure

sEH-IN-21 Chemical Structure

CAS No. : 3084814-46-7

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sEH-IN-21 相关抗体

Top Publications Citing Use of Products

查看 NF-κB 亚型特异性产品:

查看所有亚型
NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

查看 Interleukin Related 亚型特异性产品:

查看所有亚型
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

查看 TNF Receptor 亚型特异性产品:

查看所有亚型
TNFRSF1A/CD120a TNFRSF4 TNFRSF5/CD40 TNFRSF6/Fas/CD95 TNFRSF7/CD27 TNFRSF8/CD30 TNFRSF9/4-1BB/CD137 TNFRSF12A/TWEAK TNFRSF16/NGF Receptor/CD271 TNFRSF18/GITR/CD357

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

sEH-IN-21 is an orally active sEH inhibitor with IC5050s of 0.1 nM for hsEH and msEH. sEH-IN-21 potently inhibits NF-κB signaling pathways. sEH-IN-21 shows a strong anti-inflammatory activity, decreases the release of IL-6 and TNF-α and maintained the integrity of the intestinal barrier. sEH-IN-21 can be used for the study of inflammatory bowel disease (IBD)[1].

体外研究
(In Vitro)

sEH-IN-21 (Compound A1) 在鼠肝微粒体中具有较好的代谢稳定性，半衰期为 13.51 分钟，血浆蛋白结合率为 96.2%[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

sEH-IN-21 相关抗体:
体内研究
(In Vivo)

sEH-IN-21 (Compound A1) (25-100 mg/kg, p.o., 10 天) 具有抗炎活性，可通过改善肠粘膜屏障功能改善 DSS (HY-116282C) 诱导的小鼠急性结肠炎的严重程度[1]。
sEH-IN-21 (1 g/kg, i.g., 7 天) 在小鼠体内的耐受性良好，并且具有很高的安全性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: DSS-induced acute enteritis model established in male C57BL/6J mice(six-week-old).[1]
Dosage: 25, 50, 100 mg/kg
Administration: Oral gavage (p.o.), for 10 days
Result: Significantly alleviate the weight loss of mice.
Recovered the length of the colon.
Significantly reduced the histopathology of ulcerative colitis.
Increased the levels of NF-κB, TNF-α and IL-6.
Increased the expression of Occludin and Claudin.
分子量

568.73

Formula

C30H40N4O5S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

sEH-IN-21 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

sEH-IN-213084814-46-7Epoxide HydrolaseNF-κBInterleukin RelatedTNF ReceptorNuclear factor-κBNuclear factor-kappaBILTumor Necrosis Factor ReceptorTNFRinflammatory bowel diseaseDSS-induced acute enteritisInhibitorinhibitorinhibit

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