2. Protein Tyrosine Kinase/RTK Apoptosis
  3. FGFR Apoptosis Bcl-2 Family Caspase TNF Receptor
  4. Siphonaxanthin

Siphonaxanthin 是一种类酮胡萝卜素，具有抗血管生成和抗炎活性，在绿藻中发现。Siphonaxanthin 上调死亡受体5 (DR5)，诱导癌细胞凋亡 (apoptosis)，降低 Bcl-2 的表达，激活 caspase-3。Siphonaxanthin 也是 FGFR-1 的抑制剂。Siphonaxanthin 抑制人脐静脉内皮细胞 (HUVECs) 的增殖、迁移和管状形成，以及大鼠主动脉环微血管的生长。Siphonaxanthin 有望用于癌症、糖尿病视网膜病变、类风湿关节炎等疾病的研究。

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Siphonaxanthin Chemical Structure

Siphonaxanthin Chemical Structure

CAS No. : 28526-44-5

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Siphonaxanthin 相关抗体

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  • 生物活性

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  • 参考文献

生物活性

Siphonaxanthin is a keto-carotenoid with anti-angiogenic and anti-inflammatory activity, which is found in green algae. Siphonaxanthin upregulates the expression of death receptor 5 (DR5), induces cancer cell apoptosis, decreases the expression of Bcl-2, and activates caspase-3. Siphonaxanthin is also an inhibitor of FGFR-1. Siphonaxanthin inhibits the proliferation, migration, and tube formation of human umbilical vein endothelial cells (HUVECs), as well as the outgrowth of microvessels in the rat aortic ring. Siphonaxanthin is promising for research of diseases such as cancer, diabetic retinopathy, and rheumatoid arthritis[1].

分子量

600.87

Formula

C40H56O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Siphonaxanthin 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

Siphonaxanthin28526-44-5FGFRApoptosisBcl-2 FamilyCaspaseTNF ReceptorFibroblast growth factor receptorTumor Necrosis Factor ReceptorTNFRDR5apoptosisBcl-2caspase-3cancerdiabetic retinopathyand rheumatoid arthritisInhibitorinhibitorinhibit

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