2. GPCR/G Protein
  3. LPL Receptor
  4. Siponimod hemifumarate

Siponimod hemifumarate  (Synonyms: BAF-312 hemifumarate)

目录号: HY-12355A
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摩尔计算器

Siponimod (BAF-312) hemifumarate 是一种有效，选择性的鞘氨醇 -1- 磷酸 (S1P) 受体调节剂。Siponimod hemifumarate 对 S1P1 和 S1P5 受体的选择性高于 S1P2、S1P3 和 S1P4 (EC50 分别为 0.39，0.98，>10000，>1000 和 750 nM)。Siponimod hemifumarate 可用于多发性硬化症 (MS) 的研究。

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Siponimod hemifumarate Chemical Structure

Siponimod hemifumarate Chemical Structure

CAS No. : 1234627-85-0

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Siponimod hemifumarate 的其他形式现货产品:

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Siponimod hemifumarate 相关抗体

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LPAR1 LPAR2 LPAR3 LPAR5 S1PR1 S1PR2 S1PR3 S1PR4 S1PR5

  • 生物活性

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生物活性

Siponimod (BAF-312) hemifumarate is a potent and selective sphingosine-1-phosphate (S1P) receptor modulator. Siponimod hemifumarate is selective for S1P1 and S1P5 receptors over S1P2, S1P3, and S1P4 (EC50s of 0.39, 0.98, >10000, >1000, and 750 nM, respectively). Siponimod hemifumarate can be used for multiple sclerosis (MS) research[1][2].

IC50 & Target

S1PR1

0.39 nM (EC50)

S1PR5

0.98 nM (EC50)

S1PR4

750 nM (EC50)

S1PR3

>1000 nM (EC50)

S1PR2

>10000 nM (EC50)

Clinical Trial
分子量

574.63

Formula

C29H35F3N2O3.1/2C4H4O4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Siponimod hemifumarate 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Siponimod hemifumarate1234627-85-0BAF-312 hemifumarateLPL ReceptorLysophospholipid Receptormultiple sclerosisneurodegenerationinflammationsiponimodprogressiveS1P receptorS1P1 agonistlymphocytesInhibitorinhibitorinhibit

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