Sodium bicarbonate, meets analytical specification of Ph. Eur., BP, USP, FCC, E500  (Synonyms: Sodium hydrogen carbonate, meets analytical specification of Ph. Eur., BP, USP, FCC, E500)

Sodium bicarbonate, meets analytical specification of Ph. Eur., BP, USP, FCC, E500 is an inorganic salt that is neutral to slightly alkaline and easily decomposes when exposed to moisture in the air. Sodium bicarbonate can maintain the pH of the culture medium, thereby affecting the expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) production in macrophages and reversing the acidosis of the tumor microenvironment. Sodium bicarbonate is widely used in the fields of food, medicine, cosmetics, etc. Its main uses include buffers, flavoring agents, disinfectants, pharmaceuticals, and proton gradient regulators. Sodium bicarbonate is also commonly used as an antacid to inhibit gastrointestinal diseases, neutralize gastric acid, and reduce gastric discomfort^{[1][2][3][4][5][6]}.

Sodium bicarbonate (0.06-0.12 M；48 h) 显著抑制 Escherichia coli、Staphylococcus aureus、Pseudomonas aeruginosa 等细菌及 Saccharomyces cerevisiae 的生长^[2]。
Sodium bicarbonate (14-44 mM；20 h) 通过调节细胞内外 pH，浓度依赖性增强 LPS/IFNγ 刺激的 J774.1/JA-4 和 RAW264.7 巨噬细胞中 iNOS 蛋白表达及 NO 生成，44 mM 时 NO 产量提升 2.7 倍^[3]。
Sodium bicarbonate (0.3 M；6 d) 通过升高肿瘤微环境 pH 至 7.39，抑制乳腺癌细胞迁移并增强阿霉素对三阴性乳腺癌细胞的毒性，使细胞活力降至 12%^[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Sodium bicarbonate (200 mM；加入饮用水，自由口服；30 天) 显著减少肺、肠和膈肌转移瘤的数量，并提高严重联合免疫缺陷 (SCID) 小鼠 MDA-MB-231 腺癌模型中的小鼠生存率^[4][5]。
Sodium bicarbonate (0.25 g/kg；口服灌胃；单次) 在小鼠中降低 20% 酒精摄入，并显著降低 20% 酒精偏好^[6]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

84.01

NaHCO₃

144-55-8

碳酸氢钠, meets analytical specification of Ph. Eur., BP, USP, FCC, E500； 小苏打, meets analytical specification of Ph. Eur., BP, USP, FCC, E500

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Forsythe SM, et al. Sodium bicarbonate for the treatment of lactic acidosis. Chest. 2000 Jan;117(1):260-7.  [Content Brief]

  [2]. Corral L G, et al. Antimicrobial activity of sodium bicarbonate: A research note. Journal of food science, 1988, 53(3): 981-982.

  [3]. Kawakami T, et al. Sodium bicarbonate regulates nitric oxide production in mouse macrophage cell lines stimulated with lipopolysaccharide and interferon γ. Nitric Oxide. 2018 Sep 1;79:45-50.  [Content Brief]

  [4]. Robey IF, et al. Bicarbonate increases tumor pH and inhibits spontaneous metastases. Cancer Res. 2009 Mar 15;69(6):2260-8.  [Content Brief]

  [5]. Wang Y, et al. Sodium bicarbonate, an inorganic salt and a potential active agent for cancer therapy. Chinese Chemical Letters, 2021, 32(12): 3687-3695.

  [6]. Lin J, et al. Sodium Bicarbonate Decreases Alcohol Consumption in Mice. Int J Mol Sci. 2024 May 3;25(9):5006.  [Content Brief]