1. Apoptosis
  2. TNF Receptor
  3. Sotigalimab

Sotigalimab  (Synonyms: APX005M; APX005M; EPI-0050)

目录号: HY-P99049 纯度: 98.90%
COA 技术支持

Sotigalimab 是一种 CD40 激动性单克隆抗体。Sotigalimab 以高亲和力结合 CD40 并激活抗原呈递细胞,从而刺激癌症特异性 T 细胞反应。Sotigalimab 主要用于转移性胰腺癌和转移性黑色素瘤等的研究。

MCE 的所有产品仅用作科学研究或药证申报,我们不为任何个人用途提供产品和服务

CAS No. : 2305607-45-6

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 价格 是否有货 数量
1 mg ¥3000
In-stock
5 mg ¥6600
In-stock
10 mg   询价  
50 mg   询价  

* Please select Quantity before adding items.

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Sotigalimab, a CD40 agonistic monoclonal antibody. Sotigalimab binds CD40 with high affinity and activates antigen-presenting cells, thereby stimulating cancer-specific T cell responses. Sotigalimab is mainly used in the study of metastatic pancreatic cancer and metastatic melanoma[1][2].

IC50 & Target

TNFRSF5/CD40

体外研究
(In Vitro)

Sotigalimab (0-100 nM, 48 h) 可在人类原代 B 细胞中增加免疫共刺激分子 CD86 和 MHC II 的表达,从而增加 HLA-DR 的表达[3]
Sotigalimab (0-100 nM, 5 days) 可促进 T 细胞应答,刺激 T 细胞增殖和 IFN-γ 的分泌[3]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay[3]

Cell Line: Human CD8 T cell
Concentration: 0-10 nM
Incubation Time: 5 days
Result: Promoted the proliferation of tumor-infiltrating T cells.
体内研究
(In Vivo)

Sotigalimab (0.3-30 mg/kg, iv, once weekly for 4 weeks) 可在食蟹猴模型中降低外周 B 淋巴细胞的数量,而不会对其他器官系统产生不良影响[3]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Cynomolgus monkey models[3]
Dosage: 0.3-30 mg/kg
Administration: iv, once weekly for 4 weeks
Result: Reduced the number of peripheral B lymphocytes within 24 hours after administration.
Clinical Trial
基因 ID

958  [NCBI]

Accession
应用

ELISA, FACS, Functional assay

偶联物

Unconjugated

复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.

分子量

144.54 kDa

CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

Format
  • Human IgG1 kappa
纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称:

 

* 需求量:

* 客户姓名:

 

* Email:

* 电话:

 

* 公司或机构名称:

   留言给我们:

Bulk Inquiry

Inquiry Information

产品名称:
Sotigalimab
目录号:
HY-P99049
需求量: