2. Anti-infection
  3. Antibiotic Bacterial
  4. Sulfamethoxazole 1000 µg/mL in methanol

Sulfamethoxazole 1000 µg/mL in methanol  (Synonyms: Ro 4-2130 1000 µg/mL in methanol)

目录号: HY-B0322B
COA 产品使用指南 技术支持

Sulfamethoxazole (Ro 4-2130) 1000 μg/mL in methanol 是一种具有广泛抗菌活性的磺胺类抗生素 (antibiotic)。Sulfamethoxazole 1000 μg/mL in methanol 通过与 4-Aminobenzoic acid (HY-B1008) (PABA) 竞争作用于二氢蝶酸合成酶和二氢蝶酸还原酶来抑制细菌叶酸代谢。Sulfamethoxazole 1000 μg/mL in methanol 可用于研究尿路感染 (UTI)、前列腺炎和支气管炎。

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Sulfamethoxazole 1000 µg/mL in methanol Chemical Structure

Sulfamethoxazole 1000 µg/mL in methanol Chemical Structure

CAS No. : 723-46-6

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Sulfamethoxazole 1000 µg/mL in methanol 的其他形式现货产品:

Other Forms of Sulfamethoxazole 1000 µg/mL in methanol:

Sulfamethoxazole 1000 µg/mL in methanol 相关抗体

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Sulfamethoxazole (Ro 4-2130) 1000 μg/mL in methanol is a sulfonamide antibiotic with a widespread antibacterial activity. Sulfamethoxazole 1000 μg/mL in methanol inhibits bacterial folate metabolism by competing with 4-Aminobenzoic acid (HY-B1008) (PABA) to act on dihydropteroate synthetase and dihydropteroate reductase. Sulfamethoxazole 1000 μg/mL in methanol can be used for the study of urinary tract infections (UTIs), prostatitis, and bronchitis[1][2][3].

体外研究
(In Vitro)

Sulfamethoxazole (0.01-1.28 mg/mL; 120 小时) 可抑制 P. lutzii 线粒体活性[1]。
Sulfamethoxazole (0.01 mg/mL; 1-2 小时) 作用于 P. lutzii 作为氨基酸、核酸和叶酸辅因子生物合成的竞争者，破坏线粒体功能[1]。
Sulfamethoxazole 在不同浓度下，通过全细胞膜片钳记录法，在小鼠胰腺 β 细胞中抑制 KATP 通道电流，且抑制作用呈剂量依赖性，IC50 为 0.46 mM[3]。
Sulfamethoxazole 在不同浓度下，通过胰岛静态孵育实验，在小鼠胰岛中得出在高糖（10 mM）条件下低浓度（0.1 mM）即可刺激胰岛素分泌，在低糖（2 mM）条件下高浓度（10 mM）才刺激胰岛素分泌的结果[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Sulfamethoxazole 1000 µg/mL in methanol 相关抗体:

Cell Viability Assay[1]

Cell Line: P. lutzii yeast cells
Concentration: 1.28 mg/mL, 0.64 mg/mL, 0.32 mg/mL, 0.16 mg/mL, 0.08 mg/mL, 0.04 mg/mL, 0.02 mg/mL, and 0.01 mg/mL
Incubation Time: 120 h
Result: Produced a marked dose-dependent adverse effect on P. lutzii.

RT-PCR[1]

Cell Line: P. lutzii yeast cells
Concentration: 0.01 mg/mL
Incubation Time: 1 or 2 h
Result: The up-regulated genes included those for HSP70, HSP60, and HSP30.
The down-regulated genes included betaine aldehyde dehydrogenase (BADH), carnitine/acyl carnitine carrier (ACUH), guanine nucleotide binding protein α-1 subunit (GPA2), C6 transcription factor (CTF1B) and pleckstrin homology domain (PH).
Clinical Trial
分子量

253.28

Formula

C10H11N3O3S
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥90.0%

COA (286 KB)

产品使用指南 (1538 KB)
参考文献

Sulfamethoxazole 1000 µg/mL in methanol 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Sulfamethoxazole 1000 µg/mL in methanol723-46-6Ro 4-2130 1000 µg/mL in methanolAntibioticBacterialInhibitorinhibitorinhibit

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