2. Others Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease Apoptosis
  3. Reference Standards LXR FXR ROR Apoptosis
  4. T0901317 (Standard)

T0901317 (Standard) 

目录号: HY-10626R 纯度: ≥98%
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T0901317 (Standard)是 T0901317 的分析标准品。本产品用于研究及分析应用。T0901317 是口服有效且高度选择性的 LXR 激动剂，对 LXRα 的 EC50 为 20 nM。T0901317 激活 FXR，EC50 为 5 μM。T0901317 是 RORα 和 RORγ 双重反向激动剂，Ki 值分别为 132 nM 和 51 nM。T0901317 诱导细胞凋亡 (apoptosis)，并抑制低密度脂蛋白 (LDL) 受体缺失小鼠动脉粥样硬化的发展。

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T0901317 (Standard) Chemical Structure

T0901317 (Standard) Chemical Structure

CAS No. : 293754-55-9

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生物活性

T0901317 (Standard) is the analytical standard of T0901317. This product is intended for research and analytical applications. T0901317 is an orally active and highly selective LXR agonist with an EC50 of 20 nM for LXRα. T0901317 activates FXR with an EC50 of 5 μM. T0901317 is RORα and RORγ dual inverse agonist with Ki values of 132 nM and 51 nM, respectively. T0901317 induces apoptosis and inhibits the development of atherosclerosis in low-density lipoprotein (LDL) receptor-deficient mice.

分子量

481.33

Formula

C17H12F9NO3S
CAS 号
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

T0901317 (Standard) 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

T0901317 (Standard)293754-55-9Reference StandardsLXRFXRRORApoptosisLiver X receptorNR1H4RAR-related orphan receptororallyLXRαLXRβRORαRORγatherosclerosisLDLCaOV3SKOV3A2780ovariancarcinomaHS-68foreskinfibroblastsInhibitorinhibitorinhibit

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