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TAS-114 

目录号: HY-124062
产品使用指南

TAS-114 是 dUTPase二氢嘧啶脱氢酶 (DPD) 的双靶点抑制剂,可提高氟嘧啶药物的疗效。

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TAS-114 Chemical Structure

TAS-114 Chemical Structure

CAS No. : 1198221-21-4

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Description

TAS-114 is a dual dUTPase/dihydropyrimidine dehydrogenase (DPD) inhibitor, can improving the therapeutic efficacy of fluoropyrimidine[1].

IC50 & Target

dUTPase, DPD

In Vitro

TAS-114 (1-10 μM; 72 hours) increases the cytotoxicity of 5-Fluorouracil (5-FU) and 5-FU,2′-deoxy-5-fluorouridine (FdUrd) against various cancer cell lines in dose-dependent manner[1].

Cell Cytotoxicity Assay[1]

Cell Line: HeLa, NUGC-4, NCI-H441, HT-29, CFPAC-1, and MCF-7 cell lines
Concentration: 72 hours
Incubation Time: 1 μM, 3 μM, and 10 μM
Result: Clearly increased the cytotoxicity of FdUrd and 5-FU against various cancer cell lines in dose-dependent manner.
In Vivo

TAS-114 (37.5-1,200 mg/kg/day; orally; 1-14 days) increases the antitumor activity of 5-FU when co-administers with Capecitabine (539 mg/kg/day) in mice[1].

Animal Model: BALB/c nude mice with MX-1 human breast cancer xenografts[1]
Dosage: 37.5 to 1,200 mg/kg/day
Administration: Orally; daily; 1-14 days
Result: Decreased the tolerable doses of Capecitabine (539 mg/kg/day) in a dose-dependent manner in mice.
References
Molecular Weight

451.54

Formula

C₂₁H₂₉N₃O₆S

CAS No.

1198221-21-4

SMILES

O=S(CCCOCN(C(N1)=O)C=CC1=O)(N[C@@H](C2=CC=CC(OC3CCCC3)=C2)C)=O

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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产品名称:
TAS-114
目录号:
HY-124062
需求量:

TAS-114

Cat. No.: HY-124062