2. Anti-infection
  3. Bacterial
  4. TCA1

TCA1 是一种小分子，具有抗耐药性和敏感性结核分枝杆菌 (Mtb) 的活性。TCA1 抑制参与细胞壁和钼辅因子生物合成的酶，如 DprE1 和 MoeW。

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TCA1 Chemical Structure

TCA1 Chemical Structure

CAS No. : 864941-32-2

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规格 价格 是否有货 数量
Free Sample (0.1 - 0.2 mg)   Apply now  
10 mM * 1 mL in DMSO ￥1430
In-stock
1 mg ￥590
In-stock
5 mg ￥1300
In-stock
10 mg ￥1900
In-stock
25 mg ￥3500
In-stock
50 mg ￥5300
In-stock
100 mg ￥7900
In-stock
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

Customer Review

TCA1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TCA1 is a small molecule with activity against agent-susceptible and -resistant Mycobacterium tuberculosis (Mtb). TCA1 inhibits enzymes involved in cell wall and molybdenum cofactor biosynthesis, such as DprE1 and MoeW[1].

体外研究
(In Vitro)

TCA1 shows bactericidal activity against both replicating (WT and drug resistant) and nonreplicating Mycobacterium tuberculosis (Mtb). TCA1 inhibits biofilm formation by Mtb H37Rv[1].
TCA1 shows selective inhibitory activity against bacterial growth-it is inactive against Escherichia coli, Staphylococcus aureus, and Pseudomonas aeruginosa, suggesting that the target for its bactericidal activity is specific to the genus Mycobacterium[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TCA1 相关抗体:
体内研究
(In Vivo)

TCA1 (40 mg/kg; oral gavage; 1 time/d for 5 d/week; for 4 weeks) is efficacious in acute and chronic Mtb infection mouse models[1].
In a mouse model of Mtb infection, after i.v. administration, TCA1 exhibits a low clearance and steady-state volume of distribution, with an elimination half-life of 0.73 h. After oral administration of 20 and 50 mg/kg in solution formulation, TCA1 shows a high Cmax (2122 and 5653 nM, respectively), moderate exposure with oral bioavailability ranging from 19% to 46%, and a half-life of 1.8 h[1]. BALB/c mice infected with Mtb H37Rv[1] 40 mg/kg Oral gavage; 1 time/d for 5 d/week; for 4 weeks Effectively inhibits Mtb in vivo.

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

375.42

Formula

C16H13N3O4S2
CAS 号
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 125 mg/mL (332.96 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 2.6637 mL 13.3184 mL 26.6368 mL
5 mM 0.5327 mL 2.6637 mL 5.3274 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料
参考文献

TCA1 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6637 mL 13.3184 mL 26.6368 mL 66.5921 mL
5 mM 0.5327 mL 2.6637 mL 5.3274 mL 13.3184 mL
10 mM 0.2664 mL 1.3318 mL 2.6637 mL 6.6592 mL
15 mM 0.1776 mL 0.8879 mL 1.7758 mL 4.4395 mL
20 mM 0.1332 mL 0.6659 mL 1.3318 mL 3.3296 mL
25 mM 0.1065 mL 0.5327 mL 1.0655 mL 2.6637 mL
30 mM 0.0888 mL 0.4439 mL 0.8879 mL 2.2197 mL
40 mM 0.0666 mL 0.3330 mL 0.6659 mL 1.6648 mL
50 mM 0.0533 mL 0.2664 mL 0.5327 mL 1.3318 mL
60 mM 0.0444 mL 0.2220 mL 0.4439 mL 1.1099 mL
80 mM 0.0333 mL 0.1665 mL 0.3330 mL 0.8324 mL
100 mM 0.0266 mL 0.1332 mL 0.2664 mL 0.6659 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TCA1864941-32-2TCA 1TCA-1BacterialDprE1MoeWMycobacteriumtuberculosisoralInhibitorinhibitorinhibit

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产品名称：
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目录号：
HY-12904
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