2. Anti-infection
  3. Antibiotic Bacterial
  4. Telavancin

Telavancin  (Synonyms: TD-6424)

目录号: HY-112959
产品使用指南

摩尔计算器

Telavancin (TD-6424) 是一种半合成的脂糖肽万古霉素衍生物，是一种新型抗菌剂，用于克服耐药革兰氏阳性细菌感染，特别是耐甲氧西林金黄色葡萄球菌 (MRSA)。Telavancin 能够破坏细胞膜完整性，可用于革兰氏阳性菌引起的复杂皮肤和皮肤结构感染 (cSSSIs) 的研究。

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Telavancin Chemical Structure

Telavancin Chemical Structure

CAS No. : 372151-71-8

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Telavancin 相关抗体

Top Publications Citing Use of Products

查看 Antibiotic 亚型特异性产品:

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Aminoglycoside Glycopeptide Lipopeptide Macrolide Oxazolidinone Quinolone Tetracycline β-lactam

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Telavancin (TD-6424) is a semisynthetic lipoglycopeptide vancomycin-derivative, is a novel antimicrobial agent developed by Theravance for overcoming resistant Gram-positive bacterial infections, specifically methicillin-resistant Staphylococcus aureus (MRSA). Telavancin disrupts cell membrane integrity, can be used for research of complicated skin and skin structure infections (cSSSIs) caused by Gram-positive bacteria[1].

IC50 & Target

Glycopeptide

 

体外研究
(In Vitro)

Telavancin has a rapid, concentration-dependent bactericidal effect, due to disruption of cell membrane integrity[1].
Telavancin (5 μg/mL) exerts bacteriocidal effect against a MRSA strain (COL) and a VISA strain (HIP5836) at a concentration of 5 µg/mL[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Telavancin 相关抗体:
体内研究
(In Vivo)

Telavancin has been tested in various relevant animal models of infection, namely, bacteremia (40 mg/kg/d; s.c.; twice a day, with 12 h space), endocarditis (30 mg/kg/d; i.v.; twice a day, with 12 h space; 4 d), meningitis, and pneumonia with success[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: MRSA bacteremia model in neutropenic mice[1]
Dosage: 40 mg/kg
Administration: Subcutaneous injection; twice every day spaced 12 h apart 
Result: Resulted a significantly higher 14-day survival compared with vancomycin-treated animals.
Animal Model: Rabbit model of S. aureus endocarditis[1]
Dosage: 30 mg/kg
Administration: Intravenous injection; twice every day, spaced 12 h for 4 days
Result: Significantly reduced MRSA densities in all target tissues and increased the percentage of these organs rendered culture negative.
Clinical Trial
分子量

1755.63

Formula

C80H106Cl2N11O27P
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Telavancin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Telavancin372151-71-8TD-6424TD6424TD 6424AntibioticBacterialStaphylococcus aureusantimicrobialMRSAlipoglycopeptidevancomycinsemisyntheticcomplicated skin and skin structure infectionscSSSIsInhibitorinhibitorinhibit

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