2. Others Membrane Transporter/Ion Channel Anti-infection Stem Cell/Wnt TGF-beta/Smad
  3. Reference Standards Potassium Channel Parasite PKA
  4. Tetramisole hydrochloride (Standard)

Tetramisole hydrochloride (Standard)  (Synonyms: 盐酸四咪唑 (Standard); (±)-Tetramisole hydrochloride (Standard); DL-Tetramisole hydrochloride (Standard); R-829 (Standard))

目录号: HY-B1194R 纯度: ≥98%
产品使用指南 技术支持

Tetramisole hydrochloride (Standard)是 Tetramisole (hydrochloride) 的分析标准品。本产品用于研究及分析应用。Tetramisole hydrochloride 是一种口服有效、选择性的内向整流钾通道激动剂，对 Kir2.1 亚基的 EC50 约为 30 μM。Tetramisole hydrochloride 还是一种抗线虫剂，可非竞争性去极化阻断神经肌肉传递。Tetramisole hydrochloride 促进 Kir2.1 通道的正向转运、超极化静息电位 (RP)、缩短动作电位时程 (APD)，抑制细胞内钙超载及 PKA 信号通路，发挥抗心律失常和抗心肌重塑活性。Tetramisole hydrochloride 可用于心脏电生理研究心肌缺血、心力衰竭相关的研究。

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Tetramisole hydrochloride (Standard) Chemical Structure

Tetramisole hydrochloride (Standard) Chemical Structure

CAS No. : 5086-74-8

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规格 价格 是否有货 数量
25 mg ￥300
3-5 周
50 mg ￥460
3-5 周
100 mg ￥700
3-5 周
250 mg ￥1350
3-5 周
500 mg ￥2000
3-5 周
1 g   询价  
5 g   询价  

* Please select Quantity before adding items.

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生物活性

Tetramisole hydrochloride (Standard) is the analytical standard of Tetramisole (hydrochloride). This product is intended for research and analytical applications. Tetramisole hydrochloride is an orally active, selective inward rectifier potassium channel agonist with an EC50 of approximately 30 μM for the Kir2.1 subunit. Tetramisole hydrochloride is also an anti-nematode agent that blocks neuromuscular transmission by non-competitive depolarization. Tetramisole hydrochloride promotes the forward transport of Kir2.1 channels, hyperpolarizes the resting potential (RP), shortens the action potential duration (APD), inhibits intracellular calcium overload and the PKA signaling pathway, and exerts anti-arrhythmic and anti-myocardial remodeling activities. Tetramisole hydrochloride can be used in cardiac electrophysiology research and research related to myocardial ischemia and heart failure.

分子量

240.75

同用名

盐酸四咪唑 (Standard); (±)-Tetramisole hydrochloride (Standard); DL-Tetramisole hydrochloride (Standard); R-829 (Standard)

Formula

C11H13ClN2S
CAS 号
中文名称

盐酸四咪唑 (Standard)；四咪唑盐酸盐 (Standard)
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

Tetramisole hydrochloride (Standard) 相关分类

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tetramisole hydrochloride (Standard)5086-74-8(±)-Tetramisole hydrochloride (Standard)DL-Tetramisole hydrochloride (Standard)R-829 (Standard)盐酸四咪唑 (Standard)四咪唑盐酸盐 (Standard)Reference StandardsPotassium ChannelParasitePKAKcsAProtein kinase AInhibitorinhibitorinhibit

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