2. Apoptosis
  3. Apoptosis
  4. Tetrazanbigen

Tetrazanbigen 是一种强效且选择性的抗肿瘤剂。Tetrazanbigen 对六种人癌细胞系表现出强大的抗肿瘤效力，IC50 范围为 2.13-8.01 μg/mL，对正常肝细胞的 IC50 为 11.25 μg/mL。Tetrazanbigen 可诱导 QGY-7701 细胞 S 期阻滞和凋亡 (apoptosis)。Tetrazanbigen 通过诱导癌细胞中的脂质积累来发挥抗肿瘤活性。

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Tetrazanbigen Chemical Structure

Tetrazanbigen Chemical Structure

CAS No. : 2121990-04-1

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Tetrazanbigen 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tetrazanbigen is a potent and selective antitumor agent. Tetrazanbigen exhibits strong antitumor efficacy against six human cancer cell lines with an IC50 range of 2.13-8.01 μg/mL and an IC50 of 11.25 μg/mL against normal hepatocytes. Tetrazanbigen induces S phase arrest and apoptosis in QGY-7701 cells. Tetrazanbigen exerts its antitumor activity by inducing lipid accumulation accumulation in cancer cells[1].

体外研究
(In Vitro)

Tetrazanbigen (0-12 μg/mL，72 小时) 抑制 QGY-7701 细胞、BIU-87 细胞、Hep-2 细胞、SGC-7901 细胞、K562 细胞、SW626 细胞和 LO2 细胞的增殖，IC50 值分别为 2.13 μg/mL、3.25 μg/mL、3.84 μg/mL、4.41 μg/mL、7.70 μg/mL、8.01 μg/mL 和 11.25 μg/mL[1]。

Tetrazanbigen (0-8 μg/mL，24-72 小时) 诱导 QGY-7701 细胞中的脂质积累[1]。

Tetrazanbigen (2-4 μg/mL, 72 小时) 诱导 QGY-7701 细胞周期停滞于 S 期并导致细胞凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tetrazanbigen 相关抗体:

Cell Cycle Analysis[1]

Cell Line: QGY-7701 cells
Concentration: 2 μg/mL, 4 μg/mL
Incubation Time: 72 h
Result: Increased the population of S phase, decreased the populations of G0/G1 phases.

Apoptosis Analysis[1]

Cell Line: QGY-7701 cells
Concentration: 4 μg/mL
Incubation Time: 72 h
Result: Induced apoptosis, and caused condensed nuclei, apoptotic bodies and cellular shrinkage, chromatin margination.
Caused the appearance of a large number of lipid droplets.
体内研究
(In Vivo)

Tetrazanbigen (1.5 mg/kg/天，腹腔注射，5 周) 可抑制裸鼠体内的肿瘤生长且安全性较好[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Nude mice (Female athymic of 4 weeks old) bearing xenografts of QGY-7701 cell line (5 × 106, s.c.) [1]
Dosage: 1.5 mg/kg/day
Administration: i.p., 5 weeks
Result: Reduced tumor volume and inhibited tumor weight, the TGI based on tumor weight was 87%.
分子量

288.35

Formula

C18H16N4
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tetrazanbigen 相关分类

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tetrazanbigen2121990-04-1TNBGApoptosisAntineoplastic AgentsQGY-7701 cellsNude miceXenografts of QGY-7701 cell lineInhibitorinhibitorinhibit

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