2. PROTAC
  3. Ligands for E3 Ligase
  4. Thalidomide-pinacolborane

Thalidomide-pinacolborane 是一种 Thalidomide 类似物，具有硼酸频哪醇酯，也称为 Bpin 基团，它们最常用于 Suzuki 反应。该分子是 E3 连接酶的激活剂，可泛素化蛋白质，从而使其注定被蛋白水解破坏。

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Thalidomide-pinacolborane Chemical Structure

Thalidomide-pinacolborane Chemical Structure

CAS No. : 2229725-98-6

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Thalidomide-pinacolborane 相关抗体

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von Hippel-Lindau (VHL) MDM2 Cereblon IAP KLHDC2 Fbxo3 RNF4 DCAF11 DCAF1 UHRF1

  • 生物活性

  • 纯度 & 产品资料

生物活性

Thalidomide-pinacolborane is a Thalidomide analogue featuring a boronic pinacol ester, otherwise known as a Bpin group, and they are most frequently used in Suzuki reactions. This molecule is an activator for E3 ligase, which ubiquitinylates proteins, thus committing their fate to proteolytic destruction.

分子量

384.19

Formula

C19H21BN2O6
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

Thalidomide-pinacolborane 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thalidomide-pinacolborane2229725-98-6Ligands for E3 LigaseE3 ligase-recruiting MoietyInhibitorinhibitorinhibit

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产品名称：
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目录号：
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