2. Anti-infection
  3. Bacterial Fungal
  4. Thanatin

Thanatin 是一种诱导型阳离子抗菌肽。Thanatin 是一种病原体诱导的含有单二硫键的 β-发夹 AMP。Thanatin 对革兰氏阴性菌和革兰氏阳性菌以及各种真菌均表现出广谱活性，MIC 分别为 0.3-40 µM、0.6-40 µM 和 0.6-20 µM。Thanatin 具有竞争性替换细菌外膜 (OM) 上的二价阳离子的特性，从而导致 OM 破坏。

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Custom Peptide Synthesis

Thanatin Chemical Structure

Thanatin Chemical Structure

CAS No. : 214542-43-5

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Thanatin 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Thanatin is an inducible cationic antimicrobial peptide. Thanatin is a pathogen-inducible single-disulfide-bond-containing β-hairpin AMP. Thanatin displays broad-spectrum activity against both Gram-negative and Gram-positive bacteria as well as against various species of fungi with MICs of 0.3-40 µM, 0.6-40 µM and 0.6-20 µM, respectively. Thanatin has the property of competitive replacement of divalent cations from bacterial outer membrane (OM), leading to OM disruption[1][2].

体外研究
(In Vitro)

Thanatin 具有强阳离子性 (pI 为 10.48)，并包含一个独特的短八残基碱性环，该环是通过 C 末端残基 Cys11 和 Cys18 之间形成二硫键而形成的[1]。
Thanatin 在 0.4-3.2 μM 的最低抑制浓度 (MIC) 值下对所有 New Delhi metallo-β-lactamase-1 (NDM-1) 产生的大肠杆菌和肺炎克雷伯菌菌株的生长表现出有效的抑制作用[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Thanatin 相关抗体:
体内研究
(In Vivo)

Thanatin (1、3、6mg/kg；腹腔注射；1 小时和 6 小时) 可保护感染 NDM-1 产生的大肠杆菌的小鼠[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male BALB/c mice aged 8-10 weeks and weighing 18-22 g with CFU E. coli XJ141026
Dosage: 1, 3, 6 mg/kg
Administration: Intraperitoneally injected; at 1 and 6 h
Result: 1, 3, and 6 mg/kg markedly increased the survival rate from 0 to 30%, 70%, and 100%, respectively.
Showed that the bacterial titers decreased with increasing drug dose.
Rescued the pathological damages (large amounts of inflammatory cell infiltration, alveolar fusion, congestion in the spleen red pulp area, hepatic sinusoidal dilation and congestion) in a dose-dependent manner.
分子量

2433.92

Formula

C103H177N35O27S3
CAS 号
Sequence

Gly-Ser-Lys-Lys-Pro-Val-Pro-Ile-Ile-Tyr-Cys-Asn-Arg-Arg-Thr-Gly-Lys-Cys-Gln-Arg-Met (Disulfide bridge:Cys11-Cys18)
Sequence Shortening

GSKKPVPIIYCNRRTGKCQRM (Disulfide bridge:Cys11-Cys18)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Thanatin 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thanatin214542-43-5BacterialFungalCationicantimicrobialβ-hairpin AMPGram-negativeGram-positiveouter membraneInhibitorinhibitorinhibit

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目录号：
HY-P5601
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