2. Others Anti-infection Cell Cycle/DNA Damage Immunology/Inflammation Apoptosis Metabolic Enzyme/Protease
  3. Reference Standards Antibiotic Bacterial Deubiquitinase NOD-like Receptor (NLR) DNA/RNA Synthesis Pyroptosis HMG-CoA Reductase (HMGCR)
  4. Thiolutin (Standard)

Thiolutin (Standard)  (Synonyms: Acetopyrrothin (Standard))

目录号: HY-N6712R 纯度: ≥98%
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Thiolutin (Standard) 是 Thiolutin (HY-N6712) 的分析标准品。Thiolutin (Acetopyrrothin) 是一种含硫抗生素 (antibiotic)，是细菌和酵母 RNA 聚合酶的强效抑制剂。Thiolutin 可以由链霉菌产生。 Thiolutin 抑制 AMSH (IC50 = 4 μM) 和 Rpn11 (IC50 = 0.53 μM). Thiolutin 是一种 BRCC36 和 NLRP3 炎症小体双重抑制剂，具有抗炎作用。Thiolutin 能有效抑制 BRCC36 与 HMGCR 之间的相互作用，从而抑制肝细胞癌 (HCC) 的生长。Thiolutin 能减轻焦亡 (pyroptosis) 和 NLRP3 炎性小体激活。Thiolutin 能显著改善 IgA 肾病 (IgAN) 的肾损伤和炎症过程。Thiolutin 是一种抗血管生成化合物，可在小鼠模型中缓解阿霉素诱导的心脏毒性 (DOXIC)[1][2][3][4][5]。

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Thiolutin (Standard) Chemical Structure

Thiolutin (Standard) Chemical Structure

CAS No. : 87-11-6

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生物活性

Thromycin (Standard) is the analytical standard of thromycin (HY-N6712). Thiolutin (Acetopyrrothin) is a sulfur-containing antibiotic, which is a potent inhibitor of bacterial and yeast RNA polymerases. Thiolutin can be produced by Streptomyces. Thiolutin inhibits AMSH (IC50 = 4 μM) and Rpn11 (IC50 = 0.53 μM). Thiolutin is a dual inhibitor of BRCC36 and the NLRP3 inflammasome, exhibiting anti-inflammatory effects. Thiolutin effectively suppresses the interaction between BRCC36 and HMGCR, leading to the inhibition of HCC growth. Thiolutin attenuates pyroptosis and NLRP3 inflammasome activation. Thiolutin markedly alleviates renal injury and inflammatory process in IgAN. Thiolutin is an anti-angiogenic compound which can ease Doxorubicin-induced cardiotoxicity (DOXIC)[1][2][3][4][5].

分子量

228.29

Formula

C8H8N2O2S2
CAS 号
中文名称

硫藤黄素 (Standard)
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

Thiolutin (Standard) 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thiolutin (Standard)87-11-6Acetopyrrothin (Standard)硫藤黄素 (Standard)Reference StandardsAntibioticBacterialDeubiquitinaseNOD-like Receptor (NLR)DNA/RNA SynthesisPyroptosisHMG-CoA Reductase (HMGCR)DUBsNLRP3 InflammasomeIgA nephropathyInflammationHepG2 cellsliver cancerDoxorubicin CardiotoxicityInhibitorinhibitorinhibit

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