2. Immunology/Inflammation
  3. Interleukin Related
  4. Tocilizumab

Tocilizumab  (Synonyms: 托珠单抗; Anti-Human IL6R, Humanized Antibody)

目录号: HY-P9917 纯度: 98.00%
COA

摩尔计算器

Tocilizumab (Anti-Human IL6R, Humanized Antibody) 是一种抗人白细胞介素-6 受体 (IL-6R) 的中和抗体，可阻止 IL-6 与 IL-6R 的结合，从而抑制经典和反式信号。Tocilizumab 可用于类风湿性关节炎的相关研究。Tocilizumab 在重症 COVID-19 病毒方面的研究效果显著。

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Tocilizumab Chemical Structure

Tocilizumab Chemical Structure

CAS No. : 375823-41-9

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Tocilizumab 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tocilizumab (Anti-Human IL6R, Humanized Antibody) is an anti-human interleukin-6 receptor (IL-6R) neutralizing antibody, prevents binding of IL-6 to the IL-6R, thereby inhibiting both classic and trans-signaling. Tocilizumab (Anti-Human IL6R, Humanized Antibody) can be used for the treatment of rheumatoid arthritis[1]. Tocilizumab is remarkablely effective for the study of severe COVID-19 (coronavirus disease)[4].

同型

Human IgG1 kappa
推荐同型对照抗体
种属

Humanized
IC50 & Target[1][2]

IL-6

 

体外研究
(In Vitro)

Tocilizumab (抗人 IL6R，人源化抗体) (1-100 ng/mL；24 小时、48 小时) 以剂量依赖性方式抑制细胞增殖 (生长速率)，HACM 的生长速率几乎完全降低 100 ng/mL tocilizumab[2]。
Tocilizumab (抗人 IL6R，人源化抗体) (0.001-10，000 μg/mL；2 天) 抑制 Ba/F3-gp130-IL-6R 细胞用 hIL-6 刺激增殖，IC50 为 13.5 ng/mL[1]。
Tocilizumab (抗人 IL6R，人源化抗体) (1 μM；6 小时) 在体外降低 STAT3 的磷酸化，与体内 SAS 细胞一致[3]。
Tocilizumab (抗人 IL6R，人源化抗体) (1-5 μM；24 小时) 用无血清培养基显著降低SAS细胞中VEGF mRNA的表达[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tocilizumab 相关抗体:

Cell Proliferation Assay[2]

Cell Line: Human-derived HARA-B cells
Concentration: 1 ng/mL, 10 ng/mL, and 100 ng/mL
Incubation Time: 24 hours, 48 hours
Result: Inhibited the IL-6R expressed on human-derived HARA-B cells.

Cell Cytotoxicity Assay[1]

Cell Line: Ba/F3-gp130-IL-6R cells
Concentration: 0.001–10000 μg/ml
Incubation Time: 2 days
Result: Inhibited Ba/F3-gp130-IL-6R cell proliferation.

Western Blot Analysis[3]

Cell Line: SAS cells
Concentration: 1 μM
Incubation Time: 6 hours
Result: Reduced the phosphorylation of STAT3.

RT-PCR[3]

Cell Line: SAS cells
Concentration: 1-5 μM
Incubation Time: 24 hours
Result: Reduced VEGF mRNA expression.
体内研究
(In Vivo)

Tocilizumab (抗人 IL6R，人源化抗体) (静脉注射；1.0 mg/100 μL；每周两次，三周) 减少注射了 tocilizumab 的小鼠大脑中每个转移灶的体积[2]。
Tocilizumab (抗人 IL6R，人源化抗体) (腹膜内注射；100 μg/mL，每 48 小时一次；20 天) 抑制 OSCC 进展并抑制肿瘤血管生成[3]。
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MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: A brain metastasis model of lung tumor cells by inoculating HARA-B cells in nude mice[2]
Dosage: 1.0 mg/100 μL
Administration: Intravenous injection; 1.0 mg/100 μL; twice a week, three weeks
Result: Led the volume of each metastatic focus significantly smaller.
Animal Model: SCID mice with SAS cells[3]
Dosage: 100 μg/mL
Administration: Intraperitoneal injection;100 μg/mL; every 48 hours; 20days
Result: Suppressed the growth of advanced tumors.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

托珠单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 99.67%

COA (150 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Tocilizumab 相关分类

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tocilizumab375823-41-9Anti-Human IL6R, Humanized Antibody托珠单抗Interleukin RelatedILantibodyIL-6RNeutralizingrheumatoidarthritisSARS-CoV-2coronavirus diseaserespiratory failuredyspnoeaCOVID-19Inhibitorinhibitorinhibit

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