2. Apoptosis Metabolic Enzyme/Protease Immunology/Inflammation NF-κB Anti-infection Others
  3. Apoptosis Reactive Oxygen Species (ROS) Fungal Isotope-Labeled Compounds SOD Interleukin Related NF-κB Toll-like Receptor (TLR) Keap1-Nrf2
  4. Tomentosin

Tomentosin 是一种具有口服活性的天然倍半萜内酯。Tomentosin 具有抗肿瘤、抗真菌、抗炎抗氧化和神经保护等多种活性。Tomentosin 可抑制肿瘤细胞增殖、迁移和侵袭，并诱导细胞凋亡 (apoptosis)。Tomentosin 可用于肿瘤、炎症和神经系统疾病的研究。

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Tomentosin Chemical Structure

Tomentosin Chemical Structure

CAS No. : 33649-15-9

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Tomentosin 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 Interleukin Related 亚型特异性产品:

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IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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TLR3 TLR8 TLR9 TLR2 TLR4 TLR7 TLR1 TLR6

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tomentosin is an orally active natural sesquiterpenoid lactone. Tomentosin exhibits multiple activities such as anti-tumor, anti-fungal, anti-inflammatory, anti-oxidant and neuroprotective effects. Tomentosin can inhibit tumor cell proliferation, migration and invasion, and induce apoptosis. Tomentosin can be used in the research of tumors, inflammation and nervous system diseases[1][2][3][4].

IC50 & Target[2]

IL-6

 

IL-1β

 

TLR2

 

TLR4

 

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
HT-29 IC50
56.5 μM
Compound: 9
Cytostatic activity against human HT-29 cells incubated for 72 hrs by alamar blue reagent based resazurin metabolism assay
Cytostatic activity against human HT-29 cells incubated for 72 hrs by alamar blue reagent based resazurin metabolism assay
[PMID: 26218649]
MCF7 IC50
> 50 μg/mL
Compound: 17
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
Antiproliferative activity against human MCF7 cells after 48 hrs by MTT assay
[PMID: 21109433]
MCF7 IC50
26.6 μM
Compound: 9
Cytostatic activity against human MCF7 cells incubated for 6 days by alamar blue reagent based resazurin metabolism assay
Cytostatic activity against human MCF7 cells incubated for 6 days by alamar blue reagent based resazurin metabolism assay
[PMID: 26218649]
RAW264.7 IC50
15.7 μM
Compound: 9
Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced thromboxane B2 production incubated for 48 hrs by ELISA method
Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced thromboxane B2 production incubated for 48 hrs by ELISA method
[PMID: 26218649]
RAW264.7 IC50
2 μM
Compound: 11
Inhibition of LPS-induced NO production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent based assay
Inhibition of LPS-induced NO production in mouse RAW264.7 cells incubated for 24 hrs by Griess reagent based assay
[PMID: 27276091]
RAW264.7 IC50
7.14 μM
Compound: 32
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production pretreated for 30 mins before LPS challenge measured 24 hrs after LPS challenge by Griess reaction method
Antiinflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced NO production pretreated for 30 mins before LPS challenge measured 24 hrs after LPS challenge by Griess reaction method
[PMID: 21924800]
RAW264.7 IC50
7.3 μM
Compound: 9
Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced prostaglandin E2 production incubated for 48 hrs by ELISA method
Anti-inflammatory activity in mouse RAW264.7 cells assessed as inhibition of LPS-induced prostaglandin E2 production incubated for 48 hrs by ELISA method
[PMID: 26218649]
RAW264.7 IC50
9.15 μM
Compound: 12
Inhibition of LPS-induced NO production in mouse RAW264.7 cells measured after 24 hrs
Inhibition of LPS-induced NO production in mouse RAW264.7 cells measured after 24 hrs
[PMID: 20515062]
体外研究
(In Vitro)

Tomentosin (0-100 µM; 24-72 h) 可抑制胰腺癌细胞 PANC-1 和 MIA PaCa-2 增殖、迁移和侵袭，诱导细胞凋亡，并增加 ROS 水平和降低线粒体膜电位[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tomentosin 相关抗体:

Cell Viability Assay[1]

Cell Line: PANC-1 and MIA PaCa-2 cells
Concentration: 5, 10, 15, 20, 25, 30, 40, 50, 75 and 100 μM
Incubation Time: 24, 48 and 72 h
Result: Inhibited proliferation of pancreatic cancer cells in a dose- and time-dependent manner.
Had IC50 values of 147.62 μM, 31.11 μM and 22.87 μM for 24, 48 and 72 h in PANC-1 cells.
Had IC50 values of 98.08 μM, 33.93 μM and 22.14 μM for 24, 48 and 72 h in MIA PaCa-2 cells.

Cell Viability Assay[1]

Cell Line: PANC-1 cells
Concentration: 31.11 μM
Incubation Time: 48 h
Result: Increased the levels of cleaved Caspase-3, and -9.
体内研究
(In Vivo)

Tomentosin (25-50 mg/kg; 15 天) 在帕金森小鼠模型中具有神经保护的作用[2]。
Tomentosin (12.5-50 mg/kg; 灌胃; 10 天) 在心脏功能障碍小鼠模型中具有改善作用[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57/BL6 mice (23-35 g, 9-12 weeks old) treated MPTP (HY-W114750)[2]
Dosage: 25 and 50 mg/kg
Administration: 15 days
Result: Significantly prevented weight loss.
Improved motor function (evidenced by better performance in rota-rod test, grasping test, and pole-climbing test).
Reduced levels of proinflammatory cytokines (TNF-α, IL-1β, IL-6), ROS, and MPO, enhanced SOD activity.
Inhibited the expression of TLR-4, TLR-2, and NF-κB in brain tissues, and prevented glial cell damage and neuronal loss as shown by histopathological analysis.
Animal Model: Male Balb/c mice (28-33 g, 8-10 weeks old) with LPS (HY-D1056)[3]
Dosage: 12.5, 25 and 50 mg/kg
Administration: Oral gavage (i.g.); 10 days
Result: Mitigated cardiac injury and histopathological damage.
Significantly reduced Troponin and CK-MB levels.
Alleviated oxidative stress, and suppressed inflammatory responses.
Inhibited NF-κB activation while enhancing Nrf-2 expression.
分子量

248.32

Formula

C15H20O3
CAS 号
性状

固体

颜色

White to off-white

结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

溶解性数据
细胞实验： 

DMSO 中的溶解度 : 50 mg/mL (201.35 mM; 超声助溶; 吸湿的 DMSO 对产品的溶解度有显著影响，请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.0271 mL 20.1353 mL 40.2706 mL
5 mM 0.8054 mL 4.0271 mL 8.0541 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物实验：

请根据您的 实验动物和给药方式 选择适当的溶解方案。

以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；
以下溶剂前显示的百分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

  • 方案 一

    请依序添加每种溶剂： 10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 1.25 mg/mL (5.03 mM); 澄清溶液

    此方案可获得 ≥ 1.25 mg/mL（饱和度未知）的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 12.5 mg/mL 的澄清 DMSO 储备液加到 400 μL PEG300 中，混合均匀；再向上述体系中加入 50 μL Tween-80，混合均匀；然后再继续加入 450 μL 生理盐水 定容至 1 mL。

    生理盐水的配制：将 0.9 g 氯化钠，溶解于 ddH₂O 并定容至 100 mL，可以得到澄清透明的生理盐水溶液。
  • 方案 二

    请依序添加每种溶剂： 10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 1.25 mg/mL (5.03 mM); 澄清溶液

    此方案可获得 ≥ 1.25 mg/mL（饱和度未知）的澄清溶液。

    以 1 mL 工作液为例，取 100 μL 12.5 mg/mL 的澄清 DMSO 储备液加到 900 μL 20% 的 SBE-β-CD 生理盐水水溶液 中，混合均匀。

    2 g SBE-β-CD（磺丁基醚 β-环糊精）粉末定容于 10 mL 的生理盐水中，完全溶解至澄清透明。
动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
请输入您的动物体内配方组成：
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
如果您的动物是免疫缺陷鼠或者体弱鼠，建议 DMSO 中的在最后工作液体系中的占比尽量不超过 2%。
方案所需 助溶剂 包括：DMSO， ，均可在 MCE 网站选购。 ，Tween 80，均可在 MCE 网站选购。
计算结果
工作液所需浓度 : mg/mL
储备液配制方法 : mg 药物溶于 μL  DMSO（母液浓度为 mg/mL）。

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

您所需的储备液浓度超过该产品的实测溶解度，以下方案仅供参考，如有需要，请与 MCE 中国技术支持联系。
动物实验体内工作液的配制方法 : 取 μL DMSO 储备液，加入 μL 。 μL ，混合均匀至澄清，再加 μL Tween 80，混合均匀至澄清，再加 μL 生理盐水。
连续给药周期超过半月以上，请谨慎选择该方案。
请确保第一步储备液溶解至澄清状态，从左到右依次添加助溶剂。您可采用超声加热 （超声清洗仪，建议频次 20-40 kHz），涡旋吹打等方式辅助溶解。
纯度 & 产品资料
参考文献

Tomentosin 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (protect from light)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.0271 mL 20.1353 mL 40.2706 mL 100.6765 mL
5 mM 0.8054 mL 4.0271 mL 8.0541 mL 20.1353 mL
10 mM 0.4027 mL 2.0135 mL 4.0271 mL 10.0677 mL
15 mM 0.2685 mL 1.3424 mL 2.6847 mL 6.7118 mL
20 mM 0.2014 mL 1.0068 mL 2.0135 mL 5.0338 mL
25 mM 0.1611 mL 0.8054 mL 1.6108 mL 4.0271 mL
30 mM 0.1342 mL 0.6712 mL 1.3424 mL 3.3559 mL
40 mM 0.1007 mL 0.5034 mL 1.0068 mL 2.5169 mL
50 mM 0.0805 mL 0.4027 mL 0.8054 mL 2.0135 mL
60 mM 0.0671 mL 0.3356 mL 0.6712 mL 1.6779 mL
80 mM 0.0503 mL 0.2517 mL 0.5034 mL 1.2585 mL
100 mM 0.0403 mL 0.2014 mL 0.4027 mL 1.0068 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tomentosin33649-15-9ApoptosisReactive Oxygen Species (ROS)FungalIsotope-Labeled CompoundsSODInterleukin RelatedNF-κBToll-like Receptor (TLR)Keap1-Nrf2Superoxide DismutaseILNuclear factor-κBNuclear factor-kappaBParkinson's disease modelLPSPANC-1MIA PaCa-2Inhibitorinhibitorinhibit

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