2. Cell Cycle/DNA Damage Apoptosis Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Topoisomerase Apoptosis Reactive Oxygen Species
  4. Topo I-IN-1

Topo I-IN-1 (Compound 14d) 是一种具有抗肿瘤活性和 DNA 嵌入能力的 Topo I 抑制剂。Topo I-IN-1 诱导细胞凋亡 (apoptosis)。

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Topo I-IN-1 Chemical Structure

Topo I-IN-1 Chemical Structure

CAS No. : 2763655-68-9

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Topo I-IN-1 相关抗体

Top Publications Citing Use of Products

查看 Topoisomerase 亚型特异性产品:

查看所有亚型
Topoisomerase Topo I Topo II

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Topo I-IN-1 (Compound 14d) is a potent Topo I inhibitor with antitumor activity and DNA intercalative capability. Topo I-IN-1 induces cell apoptosis[1].

IC50 & Target

Topoisomerase I

 

体外研究
(In Vitro)

Topo I-IN-1 (Compound 14d) (0-50 µM, 48 h) shows antiproliferative activity against human cancer cells and has low toxicity toward normal rat kidney epithelial cells[1].
Topo I-IN-1 (0-4 µM, 48 h) shows a dose-dependent apoptotic effect, induces ROS generation, and inhibits cell migration[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Topo I-IN-1 相关抗体:

Cell Cytotoxicity Assay[1]

Cell Line: A549, HCT116, MCF7, SK-MEL-28, and NRK (normal rat kidney epithelial cells)
Concentration: 0-50 µM
Incubation Time: 48 h
Result: Showed in vitro cytotoxicity with IC50 values of 2.33 ± 1.52, 2.85 ± 0.83, 26.23 ± 2.48, 3.86 ± 0.33, and 29.99 ± 0.95 µM against A549, HCT116, MCF7, SK-MEL-28, and NRK cells, respectively.

Apoptosis Analysis[1]

Cell Line: A549
Concentration: 2, 2.33 and 4 μM
Incubation Time: 48 h
Result: Resulted in the morphological changes typical to apoptosis.
分子量

408.25

Formula

C20H14BrN3O2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Topo I-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Topo I-IN-12763655-68-9TopoisomeraseApoptosisReactive Oxygen SpeciesantitumorA549HCT116MCF7SK-MEL-28Inhibitorinhibitorinhibit

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