2. Cell Cycle/DNA Damage
  3. Telomerase
  4. TRF1-TIN2 interaction-IN-1

TRF1-TIN2 interaction-IN-1 (Compound 40) 是一种 TRF1-TIN2 相互作用抑制剂。TRF1-TIN2 interaction-IN-1 能够结合 TRF1 的 TRFH 结构域 (KD = 29 μM)，并竞争性抑制 TIN2 肽段的结合 (IC50 = 67 μM)。TRF1-TIN2 interaction-IN-1 通过占据 TRF1-TIN2 结合界面的热点处，破坏 TRF1 与 TIN2 的相互作用。TRF1-TIN2 interaction-IN-1 能够将 TRF1 从 shelterin 复合体中移除，可用于 shelterin 相关癌症的研究。

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TRF1-TIN2 interaction-IN-1 Chemical Structure

TRF1-TIN2 interaction-IN-1 Chemical Structure

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规格 价格 是否有货 数量
5 mg ￥720
1 - 3 周
10 mg ￥1125
1 - 3 周
25 mg ￥2250
1 - 3 周
50 mg ￥3690
1 - 3 周
100 mg   询价  
200 mg   询价  

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TRF1-TIN2 interaction-IN-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TRF1-TIN2 interaction-IN-1 (Compound 40) is a TRF1-TIN2 interaction inhibitor. TRF1-TIN2 interaction-IN-1 binds to the TRFH domain of TRF1 (KD = 29 μM) and competitively inhibits the binding of the TIN2 peptide (IC50 = 67 μM). TRF1-TIN2 interaction-IN-1 disrupts the interaction between TRF1 and TIN2 by occupying the hotspot region of the TRF1-TIN2 binding interface. TRF1-TIN2 interaction-IN-1 can expel TRF 1 from the shelterin complex and can be used to study shelterin-related cancers[1].

分子量

374.41

Formula

C19H18O6S
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TRF1-TIN2 interaction-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TRF1-TIN2 interaction-IN-1TelomeraseShelterincancerproteintelomeres,DNAInhibitorinhibitorinhibit

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