2. Others Membrane Transporter/Ion Channel
  3. Chloride Channel CFTR Isotope-Labeled Compounds
  4. Vanzacaftor-d4

Vanzacaftor-d4  (Synonyms: VX-121-d4)

目录号: HY-145603S
产品使用指南 技术支持

Vanzacaftor-d4 (VX-121-d4) 是氘标记的 Vanzacaftor (HY-145603)。Vanzacaftor (VX-121) 是一种口服有效的新型囊性纤维化跨膜电导调节剂 (CFTR)。Vanzacaftor 通过与 Tezacaftor (HY-15448) 和 Deutivacaftor 联合使用改善了 CFTR 蛋白的加工和运输，并增加了氯化物的运输。Vanzacaftor-Tezacaftor-Deutivacaftor 安全且耐受性良好，可改善囊性纤维化的肺功能，呼吸道症状和 CFTR 功能，有望用于囊性纤维化疾病领域的研究。

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Vanzacaftor-d<sub>4</sub> Chemical Structure

Vanzacaftor-d4 Chemical Structure

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Other Forms of Vanzacaftor-d4:

Vanzacaftor-d4 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Vanzacaftor-d4 (VX-121-d4) is the deuterium labeled Vanzacaftor (HY-145603). Vanzacaftor is an orally active noval corrector of Cystic fibrosis transmembrane conductance regulator (CFTR). Vanzacaftor improves processing and trafficking of CFTR protein as well as increases chloride transport in triple combined with Tezacaftor (HY-15448) and Deutivacaftor. Vanzacaftor-Tezacaftor-Deutivacaftor is safe and well tolerated, improving lung function, respiratory symptoms, and CFTR function with cystic fibrosis, which is promising for research in the field of cystic fibrosis diseases[1][2].

体外研究
(In Vitro)

氢、碳和其他元素的稳定重同位素已被掺入药物分子中，主要用作药物开发过程中定量的示踪剂。氘化因其可能影响药物的药代动力学和代谢特征而受到关注。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Vanzacaftor-d4 相关抗体:
分子量

621.79

Formula

C32H35D4N7O4S
非标记 CAS
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Vanzacaftor-d4 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

Vanzacaftor-d4VX-121-d4Chloride ChannelCFTRIsotope-Labeled CompoundsCl− Channels Cystic fibrosis transmembrane conductance regulatorInhibitorinhibitorinhibit

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