2. Metabolic Enzyme/Protease MAPK/ERK Pathway Stem Cell/Wnt
  3. Dipeptidyl Peptidase p38 MAPK ERK
  4. YS110

YS110 是一种人源化的抗 CD26 (DPP4) IgG1 单克隆抗体。YS110 通过小窝蛋白途径诱导 CD26 核转位。YS110 通过延迟 G2/M 细胞周期转换来抑制肿瘤细胞的增殖。YS110 通过阻断 MERS CoV S1 与 CD26 的结合来抑制中东呼吸综合症冠状病毒 (MERS-CoV) 的感染。YS110 可用于癌症或感染的研究，如恶性间皮瘤和中东呼吸综合症。

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YS110 Chemical Structure

YS110 Chemical Structure

CAS No. : 1656248-21-3

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YS110 相关抗体

Top Publications Citing Use of Products

查看 Dipeptidyl Peptidase 亚型特异性产品:

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DPP-1 DPP-2 DPP-4 DPP-8 DPP-9

查看 p38 MAPK 亚型特异性产品:

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

查看 ERK 亚型特异性产品:

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ERK ERK1 ERK2 ERK5 ERK8

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

YS110 is a humanized anti-CD26 (DPP4) IgG1 monoclonal antibody. YS110 induces CD26 nuclear translocation through the caveolin pathway. YS110 inhibits the proliferation of tumor cell by delaying G2/M cell cycle transition. YS110 inhibits the infection of Middle East respiratory syndrome coronavirus (MERS CoV) by blocking the binding of MERS CoV S1 to CD26. YS110 can be used for research on cancer or infection such as Malignant Mesothelioma and MERS[1][2][3].

同型

Human IgG1 kappa
推荐同型对照抗体
IC50 & Target[1]

p38 MAPK

 

DPP-4

 

体外研究
(In Vitro)

YS110 (0-250 μg/mL, 48 小时) 以浓度依赖的方式抑制 NCI-H2452 细胞的细胞增殖[1]。
YS110 (2 μg/mL, 24 小时) 导致 NCI-H2452 细胞 G2/M 期比例显著增加，并影响相关蛋白的表达[1]。
YS110 (2 μg/mL, 6-24 小时) 可提高 NCI-H2452 细胞中 p38 MAPK 和 ERK1/2 的激活磷酸化水平[1]。
YS110 (0-20 μg/mL, 48 小时) 以剂量依赖的方式抑制 JMN 细胞的生长[2]。
YS110 (0-4 小时) 依赖于小窝蛋白途径诱导JMN 细胞中的 CD26 核转位[2]。
YS110 (2 μg/mL, 3 小时) 显著抑制 JMN 细胞中 POLR2A 的 mRNA 和蛋白质水平[2]。
YS110 (10 μg/mL, 30 分钟) 有效抑制 JKT-hCD26WT 细胞中 MERS-CoV S1-Fc 与 CD26 的特异性结合[3]。
YS110 (40 μg/mL, 30 分钟) 显著降低了 Huh-7 细胞中的 MERS-CoV 感染率[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

YS110 相关抗体:

Cell Proliferation Assay[1]

Cell Line: NCI-H2452 cells
Concentration: 0, 0.1, 2, 10 and 250 μg/mL
Incubation Time: 48 h
Result: Inhibited the cell proliferation of NCI-H2452 cells.

Cell Cycle Analysis[1]

Cell Line: NCI-H2452 cells
Concentration: 2 μg/mL
Incubation Time: 24 h
Result: Significantly increased the proportion of G2/M phase cells with an average increase of 8 %.

Western Blot Analysis[1]

Cell Line: NCI-H2452 cells
Concentration: 2 μg/mL
Incubation Time: 6 and 24 h
Result: Significantly increased the level of p21, p-cdc2, p-cdc25C, p-p38 MAPK and p-ERK1/2.

RT-PCR[2]

Cell Line: JMN cells
Concentration: 2 μg/mL
Incubation Time: 3 h
Result: Significantly reduced the mRNA level of POLR2A.

Western Blot Analysis[2]

Cell Line: JMN cells
Concentration: 2 μg/mL
Incubation Time: 3 h
Result: Significantly reduced the protein level of POLR2A.
体内研究
(In Vivo)

YS110 (5 mg/kg 或 5 μg, 瘤内注射或腹腔注射, 每周三次) 可以显著抑制 JMN 异种移植瘤的 NOG 小鼠的肿瘤生长[1]。
YS110 (8 mg/kg 或 10 μg, 瘤内注射或腹腔注射, 每周三次) 显著抑制携带 JMN 或 MSTO/clone12 (MSTO/CD26) 肿瘤的 NOG 小鼠的肿瘤体积和重量[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: NOD/Shi-scid, IL-2 receptor gamma null (NOG) mice bearing 1×106 JMN cells[1]
Dosage: 5 mg/kg or 5 μg
Administration: Intratumoral injection of 5 mg/kg; Intraperitoneal injection (i.p.) of 5μg, combinated with Pemetrexed (HY-10820) (100 mg/kg)
Result: Significantly inhibited tumor growth, reduced Ki-67 positive cells, and increased necrotic areas.
Animal Model: NOD/Shi-scid, IL-2 receptor gamma null (NOG) mice bearing 1×106 JMN cells or MSTO/clone12 (MSTO/CD26) cells[2]
Dosage: 8 mg/kg or 10 μg
Administration: Intratumoral injection of 8 mg/kg; Intraperitoneal injection (i.p.) of 10 μg
Result: Significantly inhibited tumor volume and weight, and reduced POLR2A protein levels in tumors.
基因 ID

1803  [NCBI]

Accession
靶点

DPP4/CD26
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
CAS 号
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

YS110 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

YS1101656248-21-3YS 110YS-110Dipeptidyl Peptidasep38 MAPKERKDPPExtracellular signal regulated kinasesCD26p38MAPKMesotheliomacancerMERSInhibitorinhibitorinhibit

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