2. Metabolic Enzyme/Protease Vitamin D Related/Nuclear Receptor Stem Cell/Wnt
  3. ROR Wnt
  4. Zilovertamab

Zilovertamab  (Synonyms: 泽罗妥单抗; UC-961; Cirmtuzumab)

目录号: HY-P99201 纯度: 98.21%
COA 技术支持

Zilovertamab (UC-961) 是一种人源化抗 ROR1 单克隆抗体，可阻断 Wnt5a 诱导的 ROR1 信号通路。

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CAS No. : 2485779-13-1

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     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥3200
In-stock
5 mg ￥8900
In-stock
10 mg ￥14000
In-stock
50 mg   询价  
100 mg   询价  

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Zilovertamab 相关抗体

Top Publications Citing Use of Products

MCE 顾客使用本产品发表的 1 篇科研文献

查看 ROR 亚型特异性产品:

查看所有亚型
RORγ RORα RORβ

查看 Wnt 亚型特异性产品:

查看所有亚型
Wnt1 Wnt3 Wnt5 Wnt7

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Zilovertamab (UC-961) is a humanised monoclonal antibody against ROR1 that blocks Wnt5a-induced ROR1 signalling[1].

同型

Human IgG1 kappa
推荐同型对照抗体
种属

Humanized
IC50 & Target

Wnt5A

 

体外研究
(In Vitro)

Zilovertamab (25 和 50 μg/mL；72 小时) 可抑制高级别浆液性卵巢癌 (HGSOC) 细胞增殖[1]。
Zilovertamab (50 μg/mL；72 小时 )在转录水平上下调 CaOV3 中的 ROR1 表达水平[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Zilovertamab 相关抗体:

Cell Proliferation Assay[1]

Cell Line: CaOV3, CaOV3CisR, PEO1, and PEO4 cells
Concentration: 25 and 50 µg/mL
Incubation Time: 72 hours
Result: Reduced the proliferation of CaOV3, CaOV3CisR and PEO1.

Western Blot Analysis[1]

Cell Line: CaOV3, CaOV3CisR, PEO1, and PEO4 cells
Concentration: 50 µg/mL
Incubation Time: 72 hours
Result: Down-regulated ROR1 expression levels in CaOV3 at the transcriptional level.
Clinical Trial
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
分子量

145.12 kDa

同用名

泽罗妥单抗; UC-961; Cirmtuzumab

CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

泽罗妥单抗
运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
Format
  • Human IgG1 kappa
Biological Activity
  • Immobilized Human ROR1-ECD-His can bind Zilovertamab. The EC50 for this effect is 3.078 ng/mL.
纯度 & 产品资料

纯度: 98.21%

COA (265 KB) SDS-PAGE (186 KB) SEC-HPLC (67 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

Zilovertamab 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Zilovertamab2485779-13-1UC-961 Cirmtuzumab泽罗妥单抗UC961UC 961RORWntRAR-related orphan receptorhumanised monoclonal antibodyWnt5aROR1 signallingCaOV3Inhibitorinhibitorinhibit

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目录号：
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