1. Cell Cycle/DNA Damage Apoptosis
  2. CDK Topoisomerase Apoptosis
  3. ZLHQ-5f

ZLHQ-5f 是一种 CDK2Topo I 双重抑制剂,对 CDK2/CycA2 的 IC50 值为 0.145 μM。ZLHQ-5f 在 S 期阻滞细胞周期,诱导 HCT116 细胞凋亡 (apoptosis),具有良好安全性。

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ZLHQ-5f Chemical Structure

ZLHQ-5f Chemical Structure

CAS No. : 2851977-85-8

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

ZLHQ-5f is a dual CDK2 and Topo I inhibitor with an IC50 of 0.145 μM against CDK2/CycA2. ZLHQ-5f arrests the cell cycle in S-phase, triggers apoptosis in HCT116 cells, and has a good safety profile[1].

IC50 & Target

CDK2/CycA2

0.145 μM (IC50)

Top1

 

体外研究
(In Vitro)

ZLHQ-5f shows antiproliferative activity with GI50 values of 0.949 ± 0.113, 0.821 ± 0.240, 1.124 ± 0.362, 1.945 ± 0.278 and 3.349 ± 0.149 μM against A549, HCT116, MCF-7, HepG2 and LO2 cells, respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

463.53

Formula

C28H25N5O2

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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ZLHQ-5f
目录号:
HY-147698
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