2. Others Cell Cycle/DNA Damage Membrane Transporter/Ion Channel Apoptosis
  3. Reference Standards PERK Potassium Channel Apoptosis Eukaryotic Initiation Factor (eIF)
  4. 1,2,4-Trihydroxybenzene (Standard)

1,2,4-Trihydroxybenzene (Standard)  (Synonyms: Hydroxyhydroquinone (Standard))

目录号: HY-W010451R 纯度: ≥98%
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1,2,4-Trihydroxybenzene (Hydroxyhydroquinone) (Standard) 是 1,2,4-Trihydroxybenzene (HY-W010451) 的分析标准品。本产品用于研究及分析应用。1,2,4-Trihydroxybenzene (Hydroxyhydroquinone) 是一种内质网 (ER) 应激诱导剂，可靶向 PKR 样内质网激酶 PERK 等蛋白引发细胞毒性。1,2,4-Trihydroxybenzene 可选择性诱导 eIF2α 磷酸化，激活 PERK-eIF2α 信号通路诱导应激颗粒形成。1,2,4-Trihydroxybenzene 随后加剧氧化应激并导致 DNA 双链断裂，破坏线粒体和内质网等细胞器结构，引发细胞死亡。1,2,4-Trihydroxybenzene 还具有潜在抗癌、升高血压、解痉挛的作用。

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1,2,4-Trihydroxybenzene (Standard) Chemical Structure

1,2,4-Trihydroxybenzene (Standard) Chemical Structure

CAS No. : 533-73-3

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规格 价格 是否有货 数量
10 mg ￥250
3 - 5 周
25 mg ￥440
3 - 5 周
50 mg ￥670
3 - 5 周
100 mg ￥1000
3 - 5 周
200 mg   询价  
500 mg   询价  

* Please select Quantity before adding items.

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生物活性

1,2,4-Trihydroxybenzene (Hydroxyhydroquinone) (Standard) is the analytical standard of 1,2,4-Trihydroxybenzene (HY-W010451). This product is intended for research and analytical applications. 1,2,4-Trihydroxybenzene (Hydroxyhydroquinone) is an ER stress inducer that targets proteins such as PKR-like ER kinase PERK to induce cytotoxicity. 1,2,4-Trihydroxybenzene selectively activates eIF2α phosphorylation, activates the PERK-eIF2α signaling pathway and induces stress granule formation. 1,2,4-Trihydroxybenzene subsequently exacerbates oxidative stress and causes DNA double-strand breaks, destroying organelles such as mitochondria and ER, and inducing cell death. 1,2,4-Trihydroxybenzene also has the potential to exhibit anti-tumor effect, increase blood pressure, and relieve spasm.

分子量

126.11

Formula

C6H6O3
CAS 号
中文名称

1,2,4-三羟基苯 (Standard)
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

1,2,4-Trihydroxybenzene (Standard) 相关分类

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Keywords:

1,2,4-Trihydroxybenzene (Standard)533-73-3Hydroxyhydroquinone (Standard)1,2,4-三羟基苯 (Standard)Reference StandardsPERKPotassium ChannelApoptosisEukaryotic Initiation Factor (eIF)Protein kinase R-like endoplasmic reticulum kinasePKR-like endoplasmic reticulum kinaseKcsAInhibitorinhibitorinhibit

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