1. Signaling Pathways
  2. Cell Cycle/DNA Damage
  3. PERK


Protein kinase R (PKR)-like endoplasmic reticulum kinase (PERK) is activated in response to a variety of endoplasmic reticulum stresses implicated in numerous disease states. PERK is implicated in tumorigenesis and cancer cell survival. GSK2606414 is an orally available, potent, and selective PERK inhibitor. GSK2606414 inhibits PERK activation in cells and inhibits the growth of a human tumor xenograft in mice. PERK activation is independent of the large increase in unfolded nascent proteins within the ER following transient global brain ischemia.

PERK 相关产品 (4):

Cat. No. Product Name Effect Purity
  • HY-18072
    GSK2606414 Inhibitor 99.38%
    GSK2606414是可渗透细胞且可口服的 PERK 抑制剂,IC50值为0.4 nM。
  • HY-13820
    GSK2656157 Inhibitor 99.66%
    GSK2656157 是选择性,ATP竞争性的 PERK 抑制剂,IC50 值为 0.9 nM。
  • HY-12495
    ISRIB trans-isomer Inhibitor >98.0%
    ISRIB (trans-isomer)是高效的PERK抑制剂,IC50值为5 nM。
  • HY-119240
    CCT020312 Activator 98.56%
    CCT020312能提供有效的、具有真核起始因子 2 激酶 3 (EIF2AK3) 选择性的增殖控制,同时也是 RNA 样内质网激酶 (PERK) 的激动剂。
Isoform Specific Products

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