1. Phenylpropanoids

3,4,5-Tricaffeoylquinic acid (Synonyms: 3,4,5-triCQA)

目录号: HY-N6588
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3,4,5-Tricaffeoylquinic acid (3,4,5-triCQA) 是从铁冬青皮中得到的化合物,可用于促炎性介质诱导的皮肤病的研究。

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3,4,5-Tricaffeoylquinic acid Chemical Structure

3,4,5-Tricaffeoylquinic acid Chemical Structure

CAS No. : 86632-03-3

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Description

3,4,5-Tricaffeoylquinic acid is isolated from barks of Ilex rotunda Thunb, used in the research of the pro-inflammatory mediator-induced skin disease[1].

In Vitro

3,4,5-Tricaffeoylquinic acid (0-50 μM) reduces TNF-α-induced production of cytokines in HEK001 keratinocytes[1].
3,4,5-Tricaffeoylquinic acid (15 μM, 35 min) inhibits TNF-α-induced IkBα phosphorylation and activation of NF-κB[1].

Cell Viability Assay[1]

Cell Line: Keratinocytes
Concentration: 15, 25 and 50 μM
Incubation Time: 24 hours
Result: Cell death was cell ∼4-5% at 15 and 25 μM, ∼9% at 50 μM.

Western Blot Analysis[1]

Cell Line: Keratinocytes
Concentration: 15 μM
Incubation Time: 20 min before 10 ng/mL TNF-α addition for 15 min
Result: Decreased TNF-α-induced-IkBα phosphorylation of IkBα and levels of cytosolic NF-Κb p65, cytosolic NF-Κb p65.
References
Molecular Weight

678.59

Formula

C₃₄H₃₀O₁₅

CAS No.

86632-03-3

SMILES

OC1=C(O)C=CC(/C=C/C(O[C@H]2[C@H]([C@@H](C[C@@](C(O)=O)(O)C2)OC(/C=C/C3=CC(O)=C(O)C=C3)=O)OC(/C=C/C4=CC(O)=C(O)C=C4)=O)=O)=C1

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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This equation is commonly abbreviated as: C1V1 = C2V2

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× = ×
C1   V1   C2   V2

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产品名称:
3,4,5-Tricaffeoylquinic acid
目录号:
HY-N6588
需求量:

3,4,5-Tricaffeoylquinic acid

Cat. No.: HY-N6588