2. NF-κB MAPK/ERK Pathway PI3K/Akt/mTOR Metabolic Enzyme/Protease Immunology/Inflammation Apoptosis
  3. IKK NF-κB p38 MAPK PI3K Akt Reactive Oxygen Species Interleukin Related TNF Receptor Apoptosis Caspase Bcl-2 Family
  4. 4′-Hydroxywogonin

4′-Hydroxywogonin  (Synonyms: 8-Methoxyapigenin)

目录号: HY-N1904
产品使用指南

摩尔计算器

4′-Hydroxywogonin (8-Methoxyapigenin) 是一种黄酮类化合物，可以从 Scutellaria barbata 和 Verbena littoralis 等多种植物中分离得到。4′-Hydroxywogonin 通过 TAK1/IKK/NF-κB、MAPKs 和 PI3/AKT 信号通路具有抗炎活性。4′-Hydroxywogonin 通过干扰 PI3K/AKT 信号抑制血管生成。4′-Hydroxywogonin 抑制细胞增殖和诱导细胞凋亡 (apoptosis)。

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4′-Hydroxywogonin Chemical Structure

4′-Hydroxywogonin Chemical Structure

CAS No. : 57096-02-3

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4′-Hydroxywogonin 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

4′-Hydroxywogonin (8-Methoxyapigenin), a flavonoid, could be isolated from a variety of plants including Scutellaria barbata and Verbena littoralis. 4′-Hydroxywogonin has anti-inflammatory activity via TAK1/IKK/NF-κB, MAPKs and PI3/AKT signaling pathways. 4′-Hydroxywogonin inhibits angiogenesis by disrupting PI3K/AKT signaling. 4′-Hydroxywogonin inhibits cell proliferation and induces apoptosis[1][2][3].

体外研究
(In Vitro)

4′-Hydroxywogonin (8-Methoxyapigenin; 0.5-15 μM; 0-24 h) has low cytotoxicity and inhibits NO and PGE2 production in LPS-stimulated RAW 264.7 macrophages by suppression of iNOS and COX-2 expression[1].
4′-Hydroxywogonin (0.5-15 μM; 1 and 12 h) suppresses LPS-induced expression of pro-inflammatory cytokines in RAW 264.7 macrophages and suppresses LPS-induced activation of NF-κB[1].
4′-Hydroxywogonin (0.5-15 μM; 1 h) suppresses LPS-induced degradation of IκB-α and activation of IKK and TAK and suppresses the phosphorylation of MAPK and AKTin in RAW 264.7 macrophages[1].
4′-Hydroxywogonin (0.5-15 μM; 24 h) inhibits ROS production in LPS-stimulated RAW 264.7 macrophages[1].
4′-Hydroxywogonin (0-10 μg/mL; 24 h) reduces the viability of SW620 cells in a concentration- and time-dependent manner and decreases the mRNA and protein expression of vascular endothelial growth factor-A (VEGF-A), the predominant pro-angiogenic cytokine in tumor angiogenesis[2].
4′-Hydroxywogonin (24 h; SUP-B15 and Jurkat cells) induces apoptosis and decreases the expression of C-MYC, BCL-2 and cleaved caspase 3[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

4′-Hydroxywogonin 相关抗体:

Cell Viability Assay[1]

Cell Line: RAW 264.7 macrophages
Concentration: 0.5, 5 and 15 μM
Incubation Time: 24 hours
Result: Had low cytotoxicity in RAW 264.7 macrophages.

Western Blot Analysis[1]

Cell Line: RAW 264.7 macrophages
Concentration: 0.5, 5 and 15 μM
Incubation Time: 1 hours
Result: Attenuated the increase of iNOS and COX-2 mRNA expression induced by LPS in RAW 264.7 cells.

Western Blot Analysis[1]

Cell Line: RAW 264.7 macrophages
Concentration: 0.5, 5 and 15 μM
Incubation Time: 1 and 12 hours
Result: Reduced TNF-α, IL-6 and IL-1β mRNA expression in a dose-dependent manner.
Inhibited LPS-induced p65 phosphorylation and nuclear translocation.

Western Blot Analysis[1]

Cell Line: RAW 264.7 macrophages
Concentration: 0.5, 5 and 15 μM
Incubation Time: 1 hours
Result: Attenuated LPS induced IκB-α degradation.
Attenuated the phosphorylation of ERK1/2 and p38 in a dose-dependent manner.
Reduced the intensity of the TAK1/TAB1 band.

Western Blot Analysis[2]

Cell Line: SW620 cells
Concentration: 0.1, 1, and 10 μg/mL
Incubation Time: 24 hours
Result: Downregulated VEGF-Aexpression in colorectal cancer cells and suppressed angiogenesis.
体内研究
(In Vivo)

4′-Hydroxywogonin (10 and 20 mg/kg; i.p.; male C57BL/6 mice) alleviates LPS-induced acute lung injury (ALI) in a mouse model[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6 mice (6-8 weeks old; 20 g) with acute lung injury model[1]
Dosage: 10 and 20 mg/kg
Administration: Intraperitoneal injection, 12 and 1 h before LPS treatment
Result: Had potential protective effects against inflammation in LPS induced ALI mice.
Attenuated the degree of leukocyte infiltration.
分子量

300.26

Formula

C16H12O6
CAS 号
结构分类
初始来源
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

4′-Hydroxywogonin 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4′-Hydroxywogonin57096-02-38-MethoxyapigeninIKKNF-κBp38 MAPKPI3KAktReactive Oxygen SpeciesInterleukin RelatedTNF ReceptorApoptosisCaspaseBcl-2 FamilyIκB kinaseI kappa B kinase Nuclear factor-κBNuclear factor-kappaBPhosphoinositide 3-kinasePKBProtein kinase BILTumor Necrosis Factor ReceptorTNFRflavonoidScutellaria barbataVerbena littoralisanti-inflammatoryangiogenesisantitumorInhibitorinhibitorinhibit

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