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  3. CWHM-1008

CWHM-1008 

目录号: HY-111746
产品使用指南

CWHM-1008 是一种有效、可口服的抗疟疾剂,对药物不耐受型 Plasmodium falciparum 3D7 和耐受型 Dd2 的 EC50值分别为 46 和 21 nM。

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CWHM-1008 Chemical Structure

CWHM-1008 Chemical Structure

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2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

Size Stock
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Description

CWHM-1008 is a potent and orally active antimalarial agent, with EC50 values of 46 and 21 nM against drug-sensitive Plasmodium falciparum 3D7 and drug-resistant Dd2 strains, respectively[1].

IC50 & Target

EC50: 46 nM (Plasmodium falciparum 3D7), 21 nM (Plasmodium falciparum Dd2)[1]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (616.58 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4663 mL 12.3317 mL 24.6633 mL
5 mM 0.4933 mL 2.4663 mL 4.9327 mL
10 mM 0.2466 mL 1.2332 mL 2.4663 mL
*请根据产品在不同溶剂中的溶解度,选择合适的溶剂配制储备液。
In Vivo:
  • 1.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.13 mM); Clear solution

  • 2.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (5.13 mM); Clear solution

*以上所有助溶剂都可在 MCE 网站选购。
References
Molecular Weight

405.46

Formula

C₂₂H₂₆F₃N₃O

SMILES

C[C@H](NC([C@H]1CNC[C@@H]1C2=CC=C(C(F)(F)F)C=C2)=O)C3=CC=C(N(C)C)C=C3

Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Inquiry Information

产品名称:
CWHM-1008
目录号:
HY-111746
需求量:

CWHM-1008

Cat. No.: HY-111746