1. Metabolic Enzyme/Protease
  2. Cytochrome P450

DMU2105 

目录号: HY-101284
产品使用指南

DMU2105 是有效的特异性细胞色素 cP4501B1 (CYP1B1) 的抑制剂,其对 CYP1B1 和 CYP1A1 的 IC50 值分别为 10,742 nM。

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DMU2105 Chemical Structure

DMU2105 Chemical Structure

CAS No. : 1821143-79-6

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Size Price Stock Quantity
Free Sample (0.1-0.5 mg)   Apply now  
10 mM * 1 mL in DMSO ¥2750 In-stock
5 mg ¥2500 In-stock
10 mg ¥3500 In-stock
50 mg ¥9500 In-stock
100 mg ¥16500 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Description

DMU2105 is a potent and specific CYP1B1 inhibitor, with IC50s of 10, 742 nM for CYP1B1 and CYP1A1, respectively.

IC50 & Target

IC50: 10 nM (CYP1B1), 742 nM (CYP1A1)[1].

In Vitro

DMU2105 (Compound 7k) shows 74 and 120-fold selectivity for CYP1B1 over CYP1A1 and CYP1A2. In the presence of DMU2105 however, the EC50 goes down to 1 μM indicating that the cells had suffered from toxicity which may have been mediated by CYP1B1 inhibition. Un-transfected cells (HEK293: pcDNA3.1), when treated with cisplatin and DMU2105 (10×IC50) do not show any perceptible decrease of cisplatin EC50 (8.5 μM ± 0.9)[1].

Solvent & Solubility
In Vitro: 

DMSO : 53.33 mg/mL (205.67 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8565 mL 19.2827 mL 38.5654 mL
5 mM 0.7713 mL 3.8565 mL 7.7131 mL
10 mM 0.3857 mL 1.9283 mL 3.8565 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.67 mg/mL (10.30 mM); Suspended solution; Need ultrasonic

References
Molecular Weight

259.30

Formula

C₁₈H₁₃NO

CAS No.

1821143-79-6

SMILES

O=C(/C=C/C1=CC(C=CC=C2)=C2C=C1)C3=CC=CN=C3

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
DMU2105
目录号:
HY-101284
需求量:

DMU2105

Cat. No.: HY-101284