Ozenoxacin  (Synonyms: 奥泽沙星; T-3912)

Ozenoxacin is a nonfluorinated quinolone antibacterial, which shows potent activities against the main microorganisms isolated from skin and soft tissue infections.

Ozenoxacin (OZN) shows potent antibacterial activities against clinical isolates of Gram-positive microorganisms, with MICs ranging from 0.008 to 4 mg/L. Ozenoxacin shows good activities against strains of MRSA, MSSA, MSSE, and MRSE with 2, 3, or 4 mutations in the gyrA and grlA (parC) genes^[1]. Ozenoxacin inhibits MSSA strains and S. agalactiae strains, with the rates of resistance of >10⁻¹⁰ and 5.3 × 10⁻¹⁰, respectively. The maximum MIC value for mutant strains is 8 mg/L for ozenoxacin^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

363.41

C₂₁H₂₁N₃O₃

245765-41-7

固体

White to off-white

奥泽沙星

Room temperature in continental US; may vary elsewhere.

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 2 years; -20°C, 1 year。-80°C储存时，请在2年内使用， -20°C储存时，请在1年内使用。

• [1]. López Y, et al. In vitro activity of Ozenoxacin against quinolone-susceptible and quinolone-resistant gram-positive bacteria. Antimicrob Agents Chemother. 2013 Dec;57(12):6389-92.  [Content Brief]

  [2]. López Y, et al. In vitro selection of mutants resistant to ozenoxacin compared with levofloxacin and ciprofloxacin in Gram-positive cocci. J Antimicrob Chemother. 2015 Jan;70(1):57-61  [Content Brief]