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  2. Thyroid Hormone Receptor

PCO371 

目录号: HY-100856
产品使用指南

PCO371 是一种可口服的甲状旁腺激素受体 1 (PTHR1) 的完全抑制剂,对 PTHR2 无作用。

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PCO371 Chemical Structure

PCO371 Chemical Structure

CAS No. : 1613373-33-3

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Description

PCO371 is an orally active full agonist of parathyroid hormone receptor 1 (PTHR1), with no effect on PTH type 2 receptor.

IC50 & Target

PTHR1[1]

In Vitro

PCO371 is an orally active full agonist of parathyroid hormone receptor 1 (PTHR1), with no effect on PTH type 2 receptor. PCO371 induces cAMP production with an EC50 of 2.4 μM in COS-7 cells expressing hPTHR1, and 2.5 μM in COS-7 cells transfected with hPTHR1-delNT, and also enhances the phospholipase C activity (EC50, 17 μM)[1].

Clinical Trial
Solvent & Solubility
In Vitro: 

10 mM in DMSO

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5732 mL 7.8660 mL 15.7319 mL
5 mM 0.3146 mL 1.5732 mL 3.1464 mL
10 mM 0.1573 mL 0.7866 mL 1.5732 mL
*Please refer to the solubility information to select the appropriate solvent.
References
Molecular Weight

635.65

Formula

C₂₉H₃₂F₃N₅O₆S

CAS No.

1613373-33-3

SMILES

FC(F)(F)OC1=CC=C(C2=NC3(CCN(S(CCC4=C(C)C=C(N5C(NC(C5(C)C)=O)=O)C=C4C)(=O)=O)CC3)C(N2)=O)C=C1

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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Inquiry Information

产品名称:
PCO371
目录号:
HY-100856
需求量:

PCO371

Cat. No.: HY-100856