1. Membrane Transporter/Ion Channel
  2. P-glycoprotein

P-glycoprotein

P-glycoprotein (P-gp) also known as multidrug resistance protein 1 (MDR1) is an important protein of the cell membrane that pumps many foreign substances out of cells. More formally, it is an ATP-dependent efflux pump with broad substrate specificity. P-gp is extensively distributed and expressed in the intestinal epithelium where it pumps xenobiotics (such as toxins or drugs) back into the intestinal lumen, in liver cells where it pumps them into bile ducts, in the cells of the proximal tubular of the kidney where it pumps them into urine-conducting ducts, and in the capillary endothelial cells comprising the blood–brain barrier and blood-testis barrier, where it pumps them back into the capillaries. Some cancer cells also express large amounts of P-gp, which renders these cancers multi-drug resistant. P-gp is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood–brain barrier.

P-glycoprotein 相关产品 (22):

Cat. No. Product Name Effect Purity
  • HY-50879
    Elacridar Inhibitor 98.47%
    Elacridar 是一种有效的 P-糖蛋白 (P-glycoprotein) 和 BCRP 的抑制剂。
  • HY-17384
    Valspodar Inhibitor 99.27%
    Valspodar 是一种 p-糖蛋白 (P-gp) 抑制剂,被广泛用作克服多药耐药性调节剂。
  • HY-50671
    Zosuquidar trihydrochloride Inhibitor 98.75%
    Zosuquidar trihydrochloride是P-糖蛋白的抑制剂, Ki值为59 nM。
  • HY-10550
    Tariquidar Inhibitor 98.57%
    Tariquidar 是一种有效的特异性P-glycoprotein (P-gp)抑制剂,Kd 为 5.1±0.9 nM。
  • HY-10550A
    Tariquidar methanesulfonate, hydrate Inhibitor 98.02%
    Tariquidar methanesulfonate, hydrate是有效和特异性的 P-glycoprotein (P-gp) 抑制剂,Kd值为5.1 nM。
  • HY-106004
    Zamicastat Inhibitor
    Zamicastat 是一种浓度依赖性的双重 P-gpBCRP 抑制剂,IC50 值分别为 73.8±7.2 μM 和 17.0±2.7 μM。
  • HY-13646A
    HM30181 mesylate Inhibitor
    HM30181 mesylate 是P-糖蛋白 (P-glycoprotein) 的有效竞争性抑制剂。
  • HY-N0450
    Sinapine thiocyanate Inhibitor >98.0%
    Sinapine是来自十字花科物种的生物碱,具有抗氧化剂和放射性保护等活性。
  • HY-11018
    Risperidone Inhibitor 99.16%
    Risperidone是 5-HT2 受体的阻断剂,P-糖蛋白 (P-Glycoprotein) 的抑制剂 和 dopamine D2 受体的拮抗剂,其对 5-HT2A 和 dopamine D2 受体的 Ki 值分别为 4.8,5.9 nM。
  • HY-N0144
    Piperine Inhibitor 98.76%
    Piperine是从胡椒中分离的天然生物碱,可以抑制P-glycoprotein and CYP3A4的活性,在HeLa细胞中的IC50值为61.94±0.054 μg/mL。
  • HY-13646
    HM30181 Inhibitor
    HM30181是一种有效的选择性的P-glycoprotein抑制剂。
  • HY-15255
    Zosuquidar Inhibitor 98.33%
    Zosuquidar (LY335979)是P-糖蛋白(P-gp)介导的多药抗性负调节剂,Ki为60 nM。
  • HY-N0797
    (20S)-Protopanaxadiol Inhibitor >98.0%
    (20S)-Protopanaxadiol (20-Epiprotopanaxadiol)是protopanaxadiol型人参皂苷的糖苷配基代谢衍生物,为凋亡诱导剂。
  • HY-17013A
    Dofequidar fumarate Inhibitor 99.66%
    Dofequidar 延胡索酸盐(MS-209 延胡索酸盐)是口服活性的喹啉化合物,能抑制 ABCB1/P-gp,ABCC1/MDR-相关蛋白1。
  • HY-19626
    NSC23925 Inhibitor 99.23%
    NSC23925 是一种新型的,有选择性且有效的 P-糖蛋白 (Pgp) 抑制剂。
  • HY-N5077
    Sinapine Inhibitor 99.33%
    Sinapine是来自十字花科物种的生物碱,具有抗氧化剂和放射性保护等活性。
  • HY-17013
    Dofequidar Inhibitor
    Dofequidar(MS-209)是新型的喹啉化合物,能逆转P-糖蛋白(P-gp)介导的多药抗性。
  • HY-N0854
    Alisol F Inhibitor
    泽泻醇F (Alisol F) 是一种天然化合物。
  • HY-101530
    Polyoxyethylene stearate
    Polyoxyethylene stearate (POES) 是非离子乳化剂。
  • HY-50880
    Elacridar hydrochloride Inhibitor
    Elacridar(GF120918; GW0918)盐酸盐是P-糖蛋白抑制剂,在体内外实验中常作为工具化合物。
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