1. Cell Cycle/DNA Damage
  2. Checkpoint Kinase (Chk)

Checkpoint Kinase (Chk)

Checkpoint Kinases (Chk) are protein kinases that are involved in cell cycle control. Two checkpoint kinase subtypes have been identified, Chk1 and Chk2. Chk1 is a central component of genome surveillance pathways and is a key regulator of the cell cycle and cell survival. Chk1 is required for the initiation of DNA damage checkpoints and has recently been shown to play a role in the normal (unperturbed) cell cycle. Chk1 impacts various stages of the cell cycle including the S phase, G2/M transition and M phase. In addition to mediating cell cycle checkpoints, Chk1 also contributes to DNA repair processes, gene transcription, embryo development, cellular responses to HIV infection and somatic cell viability. Chk2 is a protein kinase that is activated in response to DNA damage and is involved in cell cycle arrest. In response to DNA damage and replication blocks, cell cycle progression is halted through the control of cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor.

Checkpoint Kinase (Chk) 相关产品 (13):

Cat. No. Product Name Effect Purity
  • HY-18174
    LY2606368 Inhibitor 99.13%
    LY2606368 是一种有效的,选择性的,ATP 竞争性的 Chk1 抑制剂,Ki 值为 0.9 nM。
  • HY-14715B
    CCT241533 hydrochloride Inhibitor 99.52%
    CCT241533 hydrochloride 是一种有效的选择性 ATP 竞争性的 CHK2 抑制剂,IC50 为 3 nM,Ki 为 1.16 nM。
  • HY-10992
    AZD-7762 Inhibitor 98.68%
    AZD-7762 是一种有效的ATP竞争性的细胞周期检测点激酶 (checkpoint kinase,Chk) 抑制剂,抑制Chk1,IC50 为 5 nM。
  • HY-15532
    SCH900776 Inhibitor 99.71%
    SCH900776 是一种有效的,选择性的,可口服的 Chk1 抑制剂,IC50 值为 3 nM;对 CDK2 和 Chk2 的抑制作用稍弱,IC50值分别为 160 nM 和 1500 nM。
  • HY-14720
    LY2603618 Inhibitor 99.61%
    LY2603618 是一种有效的选择性的 Chk1 抑制剂,IC50 为 7 nM。
  • HY-18958
    CCT245737 Inhibitor 99.17%
    CCT245737是一个强的,ATP竞争的CHK1抑制剂,IC50值是30-220 nM。
  • HY-13263
    CHIR-124 Inhibitor 98.77%
    CHIR-124 是一种有效的,选择性的 Chk1 抑制剂,IC50 值为 0.3 nM;同时可有效抑制 PDGFRFLT3IC50 值分别为 6.6 nM 和 5.8 nM。
  • HY-18174A
    LY2606368 dihydrochloride Inhibitor 99.74%
    LY2606368 dihydrochloride 是一种有效的,选择性的,ATP 竞争性的 Chk1 抑制剂,Ki 值为 0.9 nM。
  • HY-13946
    BML-277 Inhibitor 98.25%
    BML-277 是一种选择性的检测点激酶 2 (Chk2) 抑制剂,IC50 为 15 nM。
  • HY-10032
    PF 477736 Inhibitor 98.72%
    PF-477736 is a selective, potent and ATP-competitive Chk1 inhibitor with Ki of 0.49 nM and also inhibits VEGFR2, Aurora-A, FGFR3, Flt3, Fms (CSF1R), Ret and Yes; shows ~100-fold selectivity for Chk1 than Chk2.
  • HY-18175
    CCT244747 Inhibitor >98.0%
    CCT244747是一个强的,高选择性的,能够口服的,ATP竞争的CHK1抑制剂,IC50是29-170 nM。
  • HY-14715
    CCT241533 Inhibitor
    CCT241533是高活性丝氨酸/苏氨酸Chk2抑制剂,IC50为3 nM,与其它激酶有极小的交叉反应(1 uM)。
  • HY-15532B
    SCH900776 S-isomer
    SCH900776 (S-isomer)是SCH900776(HY-15532)的S型同分异构体。