1. Membrane Transporter/Ion Channel
  2. Chloride Channel

Chloride Channel

Chloride channels represent a relatively under-explored target class for drug discovery as elucidation of their identity and physiological roles has lagged behind that of many other drug targets. Chloride channels are involved in a wide range of biological functions, including epithelial fluid secretion, cell-volume regulation, neuroexcitation, smooth-muscle contraction and acidification of intracellular organelles. Mutations in several chloride channels cause human diseases, including cystic fibrosis, macular degeneration, myotonia, kidney stones, renal salt wasting and hyperekplexia. Chloride-channel modulators have potential applications in the treatment of some of these disorders, as well as in secretory diarrhoeas, polycystic kidney disease, osteoporosis and hypertension.

Chloride channel accessory proteins, also known as calcium-activated chloride channel regulators (CLCA proteins), are a family of transmembrane proteins that have been suggested to have a role in chloride conductance in epithelial cells.

Chloride Channel 相关产品 (9):

Cat. No. Product Name Effect Purity
  • HY-N0822
    Shikonin Inhibitor 99.64%
    Shikonin 是 TMEM16A 氯化物通道的抑制剂,其 IC50 值为 6.5 μM。Shikonin 也是一种特异性的 PKM2 抑制剂,而且可以抑制肿瘤坏死因子-α (TNF-α),阻止核因子-κB (NF-κB) 通路的激活。
  • HY-12693
    R(+)-IAA-94 Inhibitor 98.37%
  • HY-P0173
    Chlorotoxin Inhibitor
    Chlorotoxin是从雷蛇属以色列蝎子的毒液中提取的由36个氨基酸组成的肽段,具有抗癌活性; 抑制U251MG细胞迁移的IC50值为600 nM。
  • HY-18996
    Adjudin Inhibitor >98.0%
    Adjudin 是一种广泛研究的男性避孕试剂,具有优越的线粒体抑制作用。 Adjudin 也是一种有效的 Cl- 通道阻断剂。
  • HY-B0493
    Niflumic acid Inhibitor 99.61%
    Niflumic acid是钙离子激活的氯离子通道阻断剂,可作用于风湿性关节炎。
  • HY-101012
    NPPB Inhibitor 99.89%
    NPPB 是外向整流氯化物通道 (ORCC) 的阻断剂。
  • HY-100244
    NS1652 Inhibitor
    NS1652 是一种可逆的阴离子电导 (anion conductance) 抑制剂,在人和小鼠的红细胞中,可以抑制氯离子通道 (chloride channel),IC50 值为 1.6 μM。
  • HY-100611
    CaCCinh-A01 Inhibitor 99.60%
    CaCCinh-A01 是 TMEM16A 和钙激活氯化物通道 (CaCC) 的抑制剂,IC50 值分别为 2.1 和 10 μM。
  • HY-B0679
    Lubiprostone Activator >98.0%