1. Membrane Transporter/Ion Channel
  2. Chloride Channel

Chloride Channel

Chloride channels represent a relatively under-explored target class for drug discovery as elucidation of their identity and physiological roles has lagged behind that of many other drug targets. Chloride channels are involved in a wide range of biological functions, including epithelial fluid secretion, cell-volume regulation, neuroexcitation, smooth-muscle contraction and acidification of intracellular organelles. Mutations in several chloride channels cause human diseases, including cystic fibrosis, macular degeneration, myotonia, kidney stones, renal salt wasting and hyperekplexia. Chloride-channel modulators have potential applications in the treatment of some of these disorders, as well as in secretory diarrhoeas, polycystic kidney disease, osteoporosis and hypertension.

Chloride channel accessory proteins, also known as calcium-activated chloride channel regulators (CLCA proteins), are a family of transmembrane proteins that have been suggested to have a role in chloride conductance in epithelial cells.

Chloride Channel 相关产品 (6):

Cat. No. Product Name Effect Purity
  • HY-N0822
    Shikonin Inhibitor 99.64%
    Shikonin是一个TMEM16A chloride 通道的抑制剂,IC50值是6.5 uM.。
  • HY-12693
    R(+)-IAA-94 Inhibitor 99.80%
    R(_addition_)-IAA-94是高效氯离子通道抑制剂。
  • HY-P0173
    Chlorotoxin Inhibitor
    Chlorotoxin是从雷蛇属以色列蝎子的毒液中提取的由36个氨基酸组成的肽段,具有抗癌活性; 抑制U251MG细胞迁移的IC50值为600 nM。
  • HY-B0493
    Niflumic acid Inhibitor 99.61%
    Niflumic acid是钙离子激活的氯离子通道阻断剂,可作用于风湿性关节炎。
  • HY-B0679
    Lubiprostone Activator
    Lubiprostone(SPI-0211;RU0211)是胃肠制剂,可作用于慢性便秘。
  • HY-100611
    CaCCinh-A01 Inhibitor
    CaCCinh-A01 是 TMEM16A 和钙激活氯化物通道 (CaCC) 的抑制剂,IC50 值分别为 2.1 和 10 μM。