1. Immunology/Inflammation
  2. COX

COX

Cyclooxygenase (COX), officially known as prostaglandin-endoperoxide synthase (PTGS), is an enzyme that is responsible for formation of important biological mediators called prostanoids, including prostaglandins, prostacyclin and thromboxane. Pharmacological inhibition of COX can provide relief from the symptoms of inflammation and pain. Drugs, like Aspirin, that inhibit cyclooxygenase activity have been available to the public for about 100 years. Two cyclooxygenase isoforms have been identified and are referred to as COX-1 and COX-2. Under many circumstances the COX-1 enzyme is produced constitutively (i.e., gastric mucosa) whereas COX-2 is inducible (i.e., sites of inflammation). Non-steroidal anti-inflammatory drugs (NSAID), such as aspirin and ibuprofen, exert their effects through inhibition of COX. The main COX inhibitors are the non-steroidal anti-inflammatory drugs (NSAIDs).

COX 相关产品 (91):

Cat. No. Product Name Effect Purity
  • HY-14398
    Celecoxib Inhibitor 99.65%
    Celecoxib 是一种选择性的 COX-2 抑制剂,IC50 为 40 nM。
  • HY-14397
    Indomethacin Inhibitor >98.0%
    Indomethacin 是一种 COX1COX2 的非选择性抑制剂,常用于治疗发热、疼痛、僵硬、肿胀等症状。
  • HY-66005
    Acetaminophen Inhibitor 99.69%
    Acetaminophen (paracetamol)是选择性环氧合酶-2 (COX-2)的抑制剂,IC50值为25.8 μM。它是广泛使用的解热和止痛药。
  • HY-14654
    Aspirin Inhibitor 99.95%
    Aspirin (acetylsalicylic acid )是COX-1的抑制剂,IC50值为5 μg/mL; 常用于治疗疼痛,发烧和炎症。
  • HY-14617
    Paradol Inhibitor 98.84%
    Paradol 是一种姜科植物中发现的刺激性酚类物质。在小鼠皮肤癌变中,Paradol结合到环氧合酶 (COX-2) 活性位点,有效抑制肿瘤发展。
  • HY-59105
    SC-560 Inhibitor 99.58%
    SC-560是有效,选择性的 COX-1 抑制剂,IC50 值为9 nM。
  • HY-N0767
    Isoorientin Inhibitor 99.24%
    Isoorientin是一种有效的 COX-2 抑制剂,IC50 值为 39 μM。
  • HY-B0808
    Oxaprozin Inhibitor
    Oxaprozin 是 COX-1COX-2 的抑制剂,对人类血小板 COX-1 和 IL-1 刺激的人类滑膜细胞 COX-2 的 IC50 值分别为 2.2 和 36 μM。Oxaprozin 还能抑制 NF-κB 的活化。
  • HY-78131
    Ibuprofen Inhibitor 99.97%
    Ibuprofen 是 COX-1COX-2 的抑制剂,IC50 值分别为 13 μM 和 370 μM,具有抗炎的活性。
  • HY-13913
    NS-398 Inhibitor 99.79%
    NS-398是一种COX-2抑制剂, 100μM NS-398完全不影响COX-1活性, 而抑制COX-2活性, IC50值是3.8μM, 抑制作用呈浓度依赖性。
  • HY-17372
    Rofecoxib Inhibitor 99.81%
    Rofecoxib(MK-966,Vioxx)是COX-2抑制剂,IC50为18nM。
  • HY-B1221
    Flufenamic acid Inhibitor 99.93%
    Flufenamic acid是非甾体类抗炎药物, 是一种环氧合酶抑制剂,且抑制前列腺素的形成, 结合且降低前列腺素合成酶的活性, 及激活TRPC6。
  • HY-15036
    Diclofenac Inhibitor 99.53%
    Diclofenac是COX抑制剂,对绵羊的COX-1和-2的IC50分别为60和220 nM。
  • HY-17009
    Iguratimod Inhibitor 99.85%
    Iguratimod(T-614)是COX-2抑制剂,能抑制IL-1,IL-6,IL-8和肿瘤坏死因子的产生。
  • HY-B0008
    Sulindac Inhibitor 99.46%
    Sulindac(Clinoril)能作用于COX-1和 COX-2,抑制前列腺素合成。
  • HY-B0261
    Meloxicam Inhibitor 99.44%
    Meloxicam是非甾体抗炎化合物,作用于COX-2。
  • HY-15037
    Diclofenac Sodium Inhibitor >98.0%
    Diclofenac钠是COX抑制剂,对绵羊的COX-1和-2的IC50分别为60和220 nM。
  • HY-15030
    Naproxen Inhibitor 99.66%
    Naproxen是COX抑制剂,对COX-1和COX-2的IC50分别为8.7 _mu_M和5.2 _mu_M。
  • HY-B1227
    Carprofen Inhibitor >98.0%
    Carprofen通过抑制COX-2和前列腺素来控制炎症, 不干扰COX-1活性。
  • HY-78131B
    (R)-(-)-Ibuprofen 98.49%
    (R)-Ibuprofen是ibuprofen的低活性对映体。