1. Immunology/Inflammation
  2. COX

COX

Cyclooxygenase (COX), officially known as prostaglandin-endoperoxide synthase (PTGS), is an enzyme that is responsible for formation of important biological mediators called prostanoids, including prostaglandins, prostacyclin and thromboxane. Pharmacological inhibition of COX can provide relief from the symptoms of inflammation and pain. Drugs, like Aspirin, that inhibit cyclooxygenase activity have been available to the public for about 100 years. Two cyclooxygenase isoforms have been identified and are referred to as COX-1 and COX-2. Under many circumstances the COX-1 enzyme is produced constitutively (i.e., gastric mucosa) whereas COX-2 is inducible (i.e., sites of inflammation). Non-steroidal anti-inflammatory drugs (NSAID), such as aspirin and ibuprofen, exert their effects through inhibition of COX. The main COX inhibitors are the non-steroidal anti-inflammatory drugs (NSAIDs).

COX 相关产品 (111):

Cat. No. Product Name Effect Purity
  • HY-66005
    Acetaminophen Inhibitor 99.69%
    Acetaminophen (paracetamol)是选择性环氧合酶-2 (COX-2)的抑制剂,IC50值为25.8 μM。它是广泛使用的解热和止痛药。
  • HY-14398
    Celecoxib Inhibitor 99.65%
    Celecoxib 是一种选择性的 COX-2 抑制剂,IC50 为 40 nM。
  • HY-14397
    Indomethacin Inhibitor >98.0%
    Indomethacin 是一种 COX1COX2 的非选择性抑制剂,常用于治疗发热、疼痛、僵硬、肿胀等症状。
  • HY-14654
    Aspirin Inhibitor >99.0%
    Aspirin (acetylsalicylic acid )是COX-1的抑制剂,IC50值为5 μg/mL; 常用于治疗疼痛,发烧和炎症。
  • HY-N0904
    Ginsenoside C-K Inhibitor 98.06%
    Ginsenoside C-K 是一种 Ginsenoside Rb1 的细菌代谢物。Ginsenoside C-K 通过抑制诱生型一氧化氮合酶 (iNOS) 和 COX-2 来发挥抗炎作用。在人肝微粒体中,Ginsenoside C-K 抑制 CYP2C9CYP2A6 活性,IC50 分别为 32.0±3.6 μM和 63.6±4.2 μM。
  • HY-B2137
    S-(+)-Ketoprofen Inhibitor 99.95%
    S-(+)-Ketoprofen 是 COX-1COX-2 的有效抑制剂,IC50 值分别为 1.9 和 27 nM。
  • HY-N0523
    Gallic acid Inhibitor 99.97%
    Gallic acid 是可以抑制 COX-2 和乙酰辅酶 A 羧化酶 (ACC) 的抗氧化剂。
  • HY-18342
    Diflunisal Inhibitor 99.37%
    Diflunisal (MK-647) 是一种水杨酸盐衍生物,具有非甾体抗炎和尿酸舒缓性能,可单独用作止痛剂和类风湿关节炎患者。Diflunisal是环氧合酶 (COX) 的抑制剂。
  • HY-N0603
    Ginsenoside Rg3 Inhibitor >98.0%
    Ginsenoside Rg3 是红参的主要成分。Ginsenoside Rg3 抑制 Na+hKv1.4 通道,IC50 分别为 32.2±4.5 和 32.6±2.2 μM。Ginsenoside Rg3 还抑制 NF-κB 活性和 COX-2 表达。
  • HY-14617
    Paradol Inhibitor 98.84%
    Paradol 是一种姜科植物中发现的刺激性酚类物质。在小鼠皮肤癌变中,Paradol结合到环氧合酶 (COX-2) 活性位点,有效抑制肿瘤发展。
  • HY-13913
    NS-398 Inhibitor 99.79%
    NS-398是一种COX-2抑制剂, 100μM NS-398完全不影响COX-1活性, 而抑制COX-2活性, IC50值是3.8μM, 抑制作用呈浓度依赖性。
  • HY-17372
    Rofecoxib Inhibitor 99.95%
    Rofecoxib(MK-966,Vioxx)是COX-2抑制剂,IC50为18nM。
  • HY-B0261
    Meloxicam Inhibitor 98.07%
    Meloxicam是非甾体抗炎化合物,作用于COX-2。
  • HY-78131
    Ibuprofen Inhibitor 99.99%
    Ibuprofen 是 COX-1COX-2 的抑制剂,IC50 值分别为 13 μM 和 370 μM,具有抗炎的活性。
  • HY-B1221
    Flufenamic acid Inhibitor 99.92%
    Flufenamic acid是非甾体类抗炎药物, 是一种环氧合酶抑制剂,且抑制前列腺素的形成, 结合且降低前列腺素合成酶的活性, 及激活TRPC6。
  • HY-15036
    Diclofenac Inhibitor 99.53%
    Diclofenac是COX抑制剂,对绵羊的COX-1和-2的IC50分别为60和220 nM。
  • HY-B1227
    Carprofen Inhibitor 99.76%
    Carprofen通过抑制COX-2和前列腺素来控制炎症, 不干扰COX-1活性。
  • HY-15037
    Diclofenac Sodium Inhibitor >98.0%
    Diclofenac钠是COX抑制剂,对绵羊的COX-1和-2的IC50分别为60和220 nM。
  • HY-N1067
    Xanthohumol Inhibitor 99.68%
    Xanthohumol 是从啤酒花中分离到的黄酮类化合物,是 DGATCOX-1 和 COX-2 的抑制剂,具有抗肿瘤,抗血管生成的作用。
  • HY-B0008
    Sulindac Inhibitor 99.46%
    Sulindac(Clinoril)能作用于COX-1和 COX-2,抑制前列腺素合成。
Isoform Specific Products

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