1. Metabolic Enzyme/Protease
  2. Cytochrome P450

Cytochrome P450

Cytochrome p450 comprises a superfamily of heme-thiolate proteins named for the spectral absorbance peak of their carbon-monoxide-bound species at 450 nm. Having been found in every class of organism, including Archaea, the p450 superfamily is believed to have originated from an ancestral gene that existed over 3 billion years ago. Repeated gene duplications have subsequently given rise to one of the largest of multigene families. These enzymes are notable both for the diversity of reactions that they catalyze and the range of chemically dissimilar substrates upon which they act. Cytochrome p450s support the oxidative, peroxidative and reductive metabolism of such endogenous and xenobiotic substrates as environmental pollutants, agrochemicals, plant allelochemicals, steroids, prostaglandins and fatty acids. In humans, Cytochrome p450s are best known for their central role in phase I drug metabolism where they are of critical importance to two of the most significant problems in clinical pharmacology: drug interactions and interindividual variability in drug metabolism.

Cytochrome P450 相关产品 (47):

Cat. No. Product Name Effect Purity
  • HY-14531
    Talarozole Inhibitor 99.54%
    Talarozole 是一种有效的 CYP26A1CYP26B1 抑制剂,IC50 分别为 5.1 nM 和 0.46 nM。
  • HY-75054
    Abiraterone acetate Inhibitor 99.92%
    Abiraterone acetate 是一种口服有效的选择性的不可逆的 CYP17 抑制剂。
  • HY-12451
    FICZ 98.19%
    FICZ 是一种有效的芳香烃受体 (AHR) 激动剂,为 CYP1 的底物。
  • HY-17356
    Fenofibrate Inhibitor 99.92%
    Fenofibrate 是一种有效的 CYP2C19CYP2B6 抑制剂,IC50 分别为 0.2 μM 和 0.7 μM。Fenofibrate 也是 PPARα 激动剂,EC50 为 30 μM。
  • HY-70013
    Abiraterone Inhibitor 99.61%
    Abiraterone 是一种有效的选择性的不可逆 CYP17 抑制剂,IC50 为 2 到 4 nM。
  • HY-101217
    BI 689648 Inhibitor 99.20%
    BI 689648 是一种新型的,高选择性醛固酮合酶抑制剂,能抑制 CYP11B1CYP11B2,其 IC50 值分别为 310 和 2.1 nM。
  • HY-103392
    Stiripentol Inhibitor 99.97%
    Stiripentol (STP)是一种抗惊厥剂,其可以抑制由 CYP3A4(非竞争性)和 CYP2C19(竞争性地)介导的 CLB 向 N-desmethylclobazam(NCLB)的 N-去甲基化,其 Ki 值分别为 1.59±0.07 和 0.516±0.065 μM,IC50 值分别为 1.58 和 3.29 μM。
  • HY-100625
    BVT948 Inhibitor
    BVT948 是一种蛋白酪氨酸磷酸酶 (PTP) 的抑制剂,也可以抑制几种细胞色素 P450 (P450) 异构体和赖氨酸甲基转移酶 SETD8
  • HY-10493
    Cobicistat Inhibitor >98.0%
    Cobicistat 是一种有效的,选择性的 cytochrome P450 3A (CYP3A) 抑制剂,IC50 值为 30-285 nM。
  • HY-B0105
    Ketoconazole Inhibitor 99.67%
    Ketoconazole是咪唑类抗真菌剂,是经典的CYP3A4抑制剂,也是 CYP24A1的抑制剂。
  • HY-70006
    TOK-001 Inhibitor 99.14%
    TOK-001 是一种多功能的抗雄激素,是 CYP17 抑制剂,在去势抵抗性前列腺癌中,IC50 为 47 nM。
  • HY-B0365A
    Memantine hydrochloride Inhibitor >98.0%
    Memantine是金刚胺衍生物,对NMDA受体有较弱到适中的亲和力, 能够抑制CYP2B6和YP2D6。
  • HY-17508
    Clarithromycin Inhibitor >98.0%
  • HY-14273
    Isavuconazole Inhibitor 99.99%
    Isavuconazole 是一种水溶的苯三唑,具有抗真菌作用,同时也是 CYP3A4 的温和抑制剂。
  • HY-15996
    VT-464 Inhibitor 98.98%
    VT-464是CYP17裂解酶抑制剂,对h-Lyase的IC50为69 nM。
  • HY-N0153
    Naringin Inhibitor 99.50%
    Naringin是黄烷酮糖苷,有很多药理作用,例如抗氧化活性,降血脂,抗癌,抑制细胞色素P450酶。target: p450, IC50: 9026 uM
  • HY-B1311
    Proadifen hydrochloride Inhibitor >98.0%
    Proadifen盐酸盐是一种细胞色素P450抑制剂(IC50 = 19μM).
  • HY-10505
    Orteronel Inhibitor 99.75%
    Orteronel 是一种高度选择性的人17,20-裂解酶 (17,20-lyase),IC50 值为 38 nM。
  • HY-B1232
    Metyrapone Inhibitor >98.0%
  • HY-76316
    Bergaptol Inhibitor 99.28%
    Bergaptol是CYP3A4酶脱苄基作用的抑制剂,它的IC50是24.92 uM. 最近的研究表明它有抗增殖和抗癌性。