2. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation
  3. Cytochrome P450 Keap1-Nrf2 Heme Oxygenase (HO) Reactive Oxygen Species (ROS)
  4. CYP2E1-IN-1

CYP2E1-IN-1 (Compound 10) 是口服有效的细胞色素 P450 2E1 (CYP2E1) 抑制剂，Kd 为 7.02 μM，IC50 为 1.64 μM，Ki 为 0.897 μM。CYP2E1-IN-1 通过激活 Nrf2/HO-1 信号通路，抑制 ROS 生成，从而缓解胰腺损伤。CYP2E1-IN-1 具有显著的抗炎和抗氧化活性，能有效减轻严重急性胰腺炎 (SAP) 的炎症和氧化应激。CYP2E1-IN-1 能够用于 SAP 和其他炎症相关疾病的研究。

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CYP2E1-IN-1 Chemical Structure

CYP2E1-IN-1 Chemical Structure

CAS No. : 38205-55-9

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规格 价格 是否有货 数量
100 mg ￥200
In-stock
250 mg ￥400
In-stock
500 mg ￥640
In-stock
1 g ￥1000
In-stock
5 g ￥2480
In-stock
10 g ￥3960
In-stock
50 g   询价  

* Please select Quantity before adding items.

Customer Review

CYP2E1-IN-1 相关抗体

Top Publications Citing Use of Products

查看 Cytochrome P450 亚型特异性产品:

查看所有亚型
CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

查看 Heme Oxygenase (HO) 亚型特异性产品:

查看所有亚型
HO-1 HO-2

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

CYP2E1-IN-1 (Compound 10) is an orally active cytochrome P450 2E1 (CYP2E1) inhibitor with a Kd of 7.02 μM, an IC50 of 1.64 μM, and a Ki of 0.897 μM. CYP2E1-IN-1 activates the Nrf2/HO-1 signaling pathway and inhibits ROS production, thereby alleviating pancreatic injury. CYP2E1-IN-1 has significant anti-inflammatory and antioxidant activities and can effectively reduce inflammation and oxidative stress in severe acute pancreatitis (SAP). CYP2E1-IN-1 can be used in the study of SAP and other inflammatory-related diseases[1].

分子量

141.19

Formula

C6H7NOS
CAS 号
性状

<28°C 固体,>29°C 液体

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Store at room temperature 3 years

In solvent -80°C 2 years
-20°C 1 year
纯度 & 产品资料
参考文献

CYP2E1-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CYP2E1-IN-138205-55-9Cytochrome P450Keap1-Nrf2Heme Oxygenase (HO)Reactive Oxygen Species (ROS)CYPsHeme OxygenaseCYP450SAPCYP2E1AR42J cellsC57BL/6J miceInhibitorinhibitorinhibit

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