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DNA Alkylator/Crosslinker

DNA alkylator/crosslinker is a molecule that alkylates DNA or can cross link with DNA. DNA alkylator/crosslinker can have mutagenic, pharmaceutical, or other effects. Alkylation is the transfer of an alkyl group from one molecule to another. The alkyl group may be transferred as an alkyl carbocation, a free radical, a carbanion or a carbene. Alkylating agents are widely used in chemistry because the alkyl group is probably the most common group encountered in organic molecules. Selective alkylation, or adding parts to the chain with the desired functional groups, is used, especially if there is no commonly available biological precursor. Alkylation with only one carbon is termed methylation. In medicine, alkylation of DNA is used in chemotherapy to damage the DNA of cancer cells. Alkylation is accomplished with the class of drugs called alkylating antineoplastic agents. Crosslinking of DNA occurs when various exogenous or endogenous agents react with two different positions in the DNA. This can either occur in the same strand (intrastrand crosslink) or in the opposite strands of the DNA (interstrand crosslink). Crosslinks also occur between DNA and protein. DNA replication is blocked by crosslinks, which causes replication arrest and cell death if the crosslink is not repaired. The RAD51 family plays a role in repair.

DNA alkylator/crosslinker (26)
产品名称 目录号 简述
Altretamine HY-B0181

Altretamine (六甲蜜胺) 是DNA烷化剂。

Altretamine hydrochloride HY-B0181A

Altretamine盐酸盐是DNA烷化剂。

Bendamustine D4 HY-13567S

Bendamustine D4是Bendamustine的氘代化合物标准品。

Busulfan HY-B0245

Busulfan (白消安) 是烷化剂。

Calicheamicin HY-19609

Calicheamicin 是一种有效的 DNA 损伤细胞毒性试剂。

Carboplatin HY-17393

Carboplatin (卡铂) 能与DNA结合,干扰细胞修复。

Carmustine HY-13585

Carmustine (卡莫司汀) 是烷化剂。

Cyclophosphamide HY-17420

Cyclophosphamide 是一种合成的烷化剂,在化学上与氮芥类有关,具有抗肿瘤及免疫抑制活性。

Fotemustine HY-B0733

Fotemustine (S 10036)是亚硝基脲类烷化剂,可作用于转移的黑色素瘤。

Ifosfamide HY-17419

Ifosfamide是DNA烷化剂。

Lomustine HY-13669

Lomustine (CCNU)是用于化疗的烷基化亚硝基脲。

Melphalan HY-17575

Melphalan (美法仑; Sarcolysin; L-PAM) 为氮芥烷化剂,能将烷基结合到DNA的鸟嘌呤上。

Miriplatin HY-16325A

Miriplatin是一脂溶性铂复合物抗癌药,用于肝细胞癌(HCC)。

Mitomycin C HY-13316

Mitomycin C 是一种DNA损伤剂,能抑制DNA合成并诱导凋亡。

Oxaliplatin HY-17371

Oxaliplatin 能够抑制 DNA 合成,可用于癌症研究。

Palifosfamide HY-14798

Palifosfamide是一种新的DNA烷化剂和异环磷酰胺的活性代谢物, 具有抗癌活性。

Procarbazine Hydrochloride HY-13733

Procarbazine盐酸盐为抗肿瘤烷化剂,可作用于霍奇金氏淋巴瘤和一些脑癌。

RITA HY-13424

RITA(NSC 652287)与nutlin-3相似,能干扰p53与Mdm2的相互作用,及诱导DNA-蛋白质和DNA-DNA交联。

Satraplatin HY-17576

Satraplatin(BMS182751; BMY45594; JM216)是基于铂的抗肿瘤化合物。

SJG-136 HY-14573

SJG-136 is a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity.

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