1. Cell Cycle/DNA Damage
  2. DNA Alkylator/Crosslinker

DNA Alkylator/Crosslinker

DNA alkylator/crosslinker is a molecule that alkylates DNA or can cross link with DNA. DNA alkylator/crosslinker can have mutagenic, pharmaceutical, or other effects. Alkylation is the transfer of an alkyl group from one molecule to another. The alkyl group may be transferred as an alkyl carbocation, a free radical, a carbanion or a carbene. Alkylating agents are widely used in chemistry because the alkyl group is probably the most common group encountered in organic molecules. Selective alkylation, or adding parts to the chain with the desired functional groups, is used, especially if there is no commonly available biological precursor. Alkylation with only one carbon is termed methylation. In medicine, alkylation of DNA is used in chemotherapy to damage the DNA of cancer cells. Alkylation is accomplished with the class of drugs called alkylating antineoplastic agents. Crosslinking of DNA occurs when various exogenous or endogenous agents react with two different positions in the DNA. This can either occur in the same strand (intrastrand crosslink) or in the opposite strands of the DNA (interstrand crosslink). Crosslinks also occur between DNA and protein. DNA replication is blocked by crosslinks, which causes replication arrest and cell death if the crosslink is not repaired. The RAD51 family plays a role in repair.

DNA Alkylator/Crosslinker 相关产品 (30):

Cat. No. Product Name Effect Purity
  • HY-13316
    Mitomycin C 98.51%
    Mitomycin C 是一种DNA损伤剂,能抑制DNA合成并诱导凋亡。
  • HY-17371
    Oxaliplatin >98.0%
    Oxaliplatin 能够抑制 DNA 合成,可用于癌症研究。
  • HY-17364
    Temozolomide 98.52%
    Temozolomide 是一种 DNA 甲基化试剂。Temozolomide 是一种烷化剂,抑制细胞生长。
  • HY-13753
    Streptozocin 99.58%
    Streptozocin 是一种有效的 DNA 甲基化试剂,作用于 HL60,K562 和 C1498 细胞,IC50 分别为 11.7,904 和 1024 μg/mL。
  • HY-17393
    Carboplatin 98.25%
    Carboplatin能与DNA结合,干扰细胞修复。
  • HY-17420
    Cyclophosphamide >98.0%
    Cyclophosphamide 是一种合成的烷化剂,在化学上与氮芥类有关,具有抗肿瘤及免疫抑制活性。
  • HY-19609
    Calicheamicin 98.44%
    Calicheamicin 是一种有效的 DNA 损伤细胞毒性试剂。
  • HY-17575
    Melphalan 98.17%
    Melphalan(Sarcolysin; L-PAM)为氮芥烷化剂,能将烷基结合到DNA的鸟嘌呤上。
  • HY-17420A
    Cyclophosphamide hydrate >98.0%
    Cyclophosphamide是在癌症和自身免疫性疾病治疗中使用的一种氮芥烷基化剂。在低水平醛脱氢酶的细胞中, Cyclophosphamide作为前药, 代谢为活性化合物Phosphoramide mustard, 与DNA交联, 导致细胞死亡。
  • HY-14798
    Palifosfamide >98.0%
    Palifosfamide是一种新的DNA烷化剂和异环磷酰胺的活性代谢物, 具有抗癌活性。
  • HY-B0245
    Busulfan >98.0%
    Busulfan是烷化剂。
  • HY-14573
    SJG-136 >98.0%
    SJG-136是一种新型合理的DNA小沟间交联剂,具有有效的广谱抗肿瘤活性。
  • HY-13424
    RITA
    RITA(NSC 652287)与nutlin-3相似,能干扰p53与Mdm2的相互作用,及诱导DNA-蛋白质和DNA-DNA交联。
  • HY-13585
    Carmustine 99.86%
    Carmustine是烷化剂。
  • HY-B0733
    Fotemustine
    Fotemustine (S 10036)是亚硝基脲类烷化剂,可作用于转移的黑色素瘤。
  • HY-13669
    Lomustine >98.0%
    Lomustine (CCNU)是用于化疗的烷基化亚硝基脲。
  • HY-17576
    Satraplatin
    Satraplatin(BMS182751; BMY45594; JM216)是基于铂的抗肿瘤化合物。
  • HY-16513
    VAL-083 >98.0%
    VAL-083为烷化剂,能较TMZ更好地抑制U251和SF188细胞的单层增殖,可诱导凋亡。
  • HY-17574
    Thio-TEPA 98.54%
    Thio-TEPA(Thioplex; Tiofosfamid)是抗癌烷化剂。
  • HY-13733
    Procarbazine Hydrochloride
    Procarbazine盐酸盐为抗肿瘤烷化剂,可作用于霍奇金氏淋巴瘤和一些脑癌。