首页 产品 化合物库 服务 Kit 关于我们 联系我们

信号通路

在线客服 在线询单 如何订购 促销产品 销售网络 定制服务

在线询价

温馨提示:客服在线时为9:00-18:00,
其他时间可发邮件至sales@medchemexpress.cn,我们会尽快回复您。

DNA Alkylator/Crosslinker

DNA alkylator/crosslinker is a molecule that alkylates DNA or can cross link with DNA. DNA alkylator/crosslinker can have mutagenic, pharmaceutical, or other effects. Alkylation is the transfer of an alkyl group from one molecule to another. The alkyl group may be transferred as an alkyl carbocation, a free radical, a carbanion or a carbene. Alkylating agents are widely used in chemistry because the alkyl group is probably the most common group encountered in organic molecules. Selective alkylation, or adding parts to the chain with the desired functional groups, is used, especially if there is no commonly available biological precursor. Alkylation with only one carbon is termed methylation. In medicine, alkylation of DNA is used in chemotherapy to damage the DNA of cancer cells. Alkylation is accomplished with the class of drugs called alkylating antineoplastic agents. Crosslinking of DNA occurs when various exogenous or endogenous agents react with two different positions in the DNA. This can either occur in the same strand (intrastrand crosslink) or in the opposite strands of the DNA (interstrand crosslink). Crosslinks also occur between DNA and protein. DNA replication is blocked by crosslinks, which causes replication arrest and cell death if the crosslink is not repaired. The RAD51 family plays a role in repair.

DNA alkylator/crosslinker (26)
产品名称 目录号 简述
Altretamine HY-B0181

Altretamine (六甲蜜胺) 是DNA烷化剂。

Altretamine hydrochloride HY-B0181A

Altretamine盐酸盐是DNA烷化剂。

Bendamustine D4 HY-13567S

Bendamustine D4是Bendamustine的氘代化合物标准品。

Busulfan HY-B0245

Busulfan (白消安) 是烷化剂。

Calicheamicin HY-19609

Calicheamicin is a potent DNA-binding cytotoxic antibiotic.

Carboplatin HY-17393

Carboplatin (卡铂) 能与DNA结合,干扰细胞修复。

Carmustine HY-13585

Carmustine (卡莫司汀) 是烷化剂。

Cyclophosphamide HY-17420

Cyclophosphamide是烷化剂。

Fotemustine HY-B0733

Fotemustine (S 10036)是亚硝基脲类烷化剂,可作用于转移的黑色素瘤。

Ifosfamide HY-17419

Ifosfamide是DNA烷化剂。

Lomustine HY-13669

Lomustine (CCNU)是用于化疗的烷基化亚硝基脲。

Melphalan HY-17575

Melphalan (美法仑; Sarcolysin; L-PAM) 为氮芥烷化剂,能将烷基结合到DNA的鸟嘌呤上。

Miriplatin HY-16325A

Miriplatin是一脂溶性铂复合物抗癌药,用于肝细胞癌(HCC)。

Mitomycin C HY-13316

Mitomycin C 是DNA交联剂,能抑制DNA合成并诱导凋亡。

Oxaliplatin HY-17371

Oxaliplatin (奥沙利铂) 可通过与DNA的偶联抑制DNA合成。

Palifosfamide HY-14798

Palifosfamide (ZIO-201)是ifosfamide (IFOS)的活性代谢物,为DNA烷化剂,可作用于软组织肉瘤(STS)。

Procarbazine Hydrochloride HY-13733

Procarbazine盐酸盐为抗肿瘤烷化剂,可作用于霍奇金氏淋巴瘤和一些脑癌。

RITA HY-13424

RITA(NSC 652287)与nutlin-3相似,能干扰p53与Mdm2的相互作用,及诱导DNA-蛋白质和DNA-DNA交联。

Satraplatin HY-17576

Satraplatin(BMS182751; BMY45594; JM216)是基于铂的抗肿瘤化合物。

SJG-136 HY-14573

SJG-136 is a novel rationally designed DNA minor groove interstrand cross-linking agent with potent and broad spectrum antitumor activity.

Tags: DNA alkylator/crosslinker 抑制 | DNA alkylator/crosslinker 蛋白 | DNA alkylator/crosslinker 抑制剂 | DNA alkylator/crosslinker FDA上市药物 | DNA alkylator/crosslinker 和癌症 | DNA alkylator/crosslinker 活性 | DNA alkylator/crosslinker 激活 | DNA alkylator/crosslinker 信号通路 | DNA alkylator/crosslinker 抑制剂筛选 | DNA alkylator/crosslinker 高通量筛选 | DNA alkylator/crosslinker 抑制剂临床 | DNA alkylator/crosslinker 抑制剂药物 | DNA alkylator/crosslinker 抑制剂综述 | DNA alkylator/crosslinker 抑制剂研发 | DNA alkylator/crosslinker 抑制剂供应商 | DNA alkylator/crosslinker 抑制剂分销商

SiteMap

MCE所有的产品和服务只应用于科学研究,我们不提供产品和服务给任何个人。

Copyright © 2013-2014 MedChemexpress All Rights Reserved 沪ICP备15051369号-1