1. Cell Cycle/DNA Damage
  2. DNA Alkylator/Crosslinker

DNA Alkylator/Crosslinker

DNA alkylator/crosslinker is a molecule that alkylates DNA or can cross link with DNA. DNA alkylator/crosslinker can have mutagenic, pharmaceutical, or other effects. Alkylation is the transfer of an alkyl group from one molecule to another. The alkyl group may be transferred as an alkyl carbocation, a free radical, a carbanion or a carbene. Alkylating agents are widely used in chemistry because the alkyl group is probably the most common group encountered in organic molecules. Selective alkylation, or adding parts to the chain with the desired functional groups, is used, especially if there is no commonly available biological precursor. Alkylation with only one carbon is termed methylation. In medicine, alkylation of DNA is used in chemotherapy to damage the DNA of cancer cells. Alkylation is accomplished with the class of drugs called alkylating antineoplastic agents. Crosslinking of DNA occurs when various exogenous or endogenous agents react with two different positions in the DNA. This can either occur in the same strand (intrastrand crosslink) or in the opposite strands of the DNA (interstrand crosslink). Crosslinks also occur between DNA and protein. DNA replication is blocked by crosslinks, which causes replication arrest and cell death if the crosslink is not repaired. The RAD51 family plays a role in repair.

DNA Alkylator/Crosslinker 相关产品 (31):

Cat. No. Product Name Effect Purity
  • HY-17394
    Cisplatin >99.0%
    Cisplatin 是一种抗肿瘤化疗药物,它与 DNA 交联引起癌细胞中DNA损伤。
  • HY-13316
    Mitomycin C 98.89%
    Mitomycin C是一种抗肿瘤药物和抗生素,可有效的抑制DNA合成 (DNA synthesis)。
  • HY-17371
    Oxaliplatin 99.57%
    Oxaliplatin是一种 DNA 合成 抑制剂。 它会导致DNA交联损伤,阻止DNA复制和转录并导致细胞死亡。
  • HY-17364
    Temozolomide 99.96%
  • HY-13753
    Streptozocin 99.58%
    Streptozocin是一种有效的 DNA甲基化 试剂,在HL60,K562和C1498细胞中的IC50 分别为11.7,904 和 1024 μg/mL。
  • HY-17575
    Melphalan >98.0%
    Melphalan 是一种有效的 DNA 烷化剂 (DNA alkylator),具有抗肿瘤活性。
  • HY-13544
    Uramustine 98.48%
    Uramustine 是一种可口服的烷化剂 (alkylator),可用于治疗淋巴肉瘤、慢性淋巴性白血病和血小板增多症。
  • HY-17420
    Cyclophosphamide >98.0%
  • HY-17393
    Carboplatin 98.25%
    Carboplatin是一种 DNA 合成 抑制剂,其与DNA结合,抑制复制和转录并诱导细胞死亡。 卡铂是顺铂的衍生物,是一种有效的抗癌剂。
  • HY-19609
    Calicheamicin 98.44%
    Calicheamicin 是一种有效的细胞毒性试剂,可引起DNA双链断裂。
  • HY-17420A
    Cyclophosphamide hydrate >98.0%
    Cyclophosphamide是在癌症和自身免疫性疾病治疗中使用的一种氮芥烷基化剂。在低水平醛脱氢酶的细胞中, Cyclophosphamide作为前药, 代谢为活性化合物Phosphoramide mustard, 与DNA交联, 导致细胞死亡。
  • HY-B0245
    Busulfan >98.0%
    Busulfan 是一种有效的烷化剂 (alkylator),具有化疗作用。
  • HY-13585
    Carmustine 99.85%
    Carmustine 是一种抗肿瘤化疗剂,为 DNARNA 的烷化剂 (alkylator)。
  • HY-B0077
    Bendamustine hydrochloride >98.0%
    Bendamustine hydrochloride 是一种 DNA 交联剂 (DNA crosslinker),能够导致 DNA 断裂,具有烷基化和抗代谢物的作用。
  • HY-17419
    Ifosfamide >98.0%
    Ifosfamide 是一种烷化剂 (DNA alkylator),具有广谱的抗肿瘤作用。
  • HY-13424
    RITA 是一种有效的 p53-HDM-2 相互作用抑制剂,可与 p53dN 结合,Kd 值为 1.5 nM,同时能够诱导 DNA-DNA 交联。
  • HY-14573
    SJG-136 >98.0%
    SJG-136 是一种有效的 DNA 交联剂 (DNA crosslinker),与 pBR322 DNA 交联的 XL50 值为 45 nM;SJG-136 具有抗肿瘤作用。
  • HY-13669
    Lomustine >98.0%
    Lomustine 是一种 DNA 烷化剂 (DNA alkylator),具有抗肿瘤活性。
  • HY-B0733
    Fotemustine 是一种 DNA 烷化剂 (DNA alkylator),具有抗肿瘤作用。
  • HY-17574
    Thio-TEPA >98.0%
    Thio-TEPA 是一种 DNA 烷化剂 (DNA alkylator),具有抗肿瘤作用。
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