1. Cell Cycle/DNA Damage
    PI3K/Akt/mTOR
  2. DNA-PK
  3. STL127705

STL127705 

目录号: HY-122727
产品使用指南

STL127705 (Compound L) 是一种 Ku 70/80 异二聚体蛋白 (Ku 70/80 heterodimer protein) 抑制剂,抑制 Ku70/80-DNA 相互作用,IC50 值为 3.5 μM。STL127705 可抑制 Ku 依赖性 DNA-PKCS 激酶的活化,IC50 值为 2.5 μM。

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STL127705 Chemical Structure

STL127705 Chemical Structure

CAS No. : 1326852-06-5

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Description

STL127705 (Compound L) is a Ku 70/80 heterodimer protein inhibitor, inhibits Ku70/80-DNA interaction, with an IC50 of 3.5 μM. STL127705 also inhibits Ku-dependent activation of DNA-PKCS kinase (IC50, 2.5 μM)[1].

IC50 & Target

IC50: 3.5 μM (Ku 70/80), 2.5 μM (DNA-PKCS)[1]

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
Molecular Weight

437.42

Formula

C₂₂H₂₀FN₅O₄

CAS No.

1326852-06-5

SMILES

O=C1NC2=NC(NCCC3=CC=C(OC)C(OC)=C3)=NC=C2C(N1C4=CC=CC(F)=C4)=O

Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
STL127705
目录号:
HY-122727
需求量:

STL127705

Cat. No.: HY-122727