1. Metabolic Enzyme/Protease
  2. Elastase

Elastase

Elastases are proteinases capable of solubilizing fibrous elastin. Elastases may belong to the class of serine proteinases, cysteine proteinases and metalloproteinases. Mammalian elastases occur mainly in the pancreas and the phagocytes. Among non-mammalian elastases there is a great variety of bacterial metallo and serine elastases. The elastolytic activity varies from one elastase to another and is usually not correlated with the catalytic efficiency of these proteinases. One may measure this activity using native or labelled elastins. With pure elastases one may use synthetic substrates. There is a large number of natural (proteins) and synthetic elastase inhibitors. Elastases play a pathologic role in pulmonary emphysema, cystic fibrosis, infections, inflammation and atherosclerosis.

Elastase 相关产品 (12):

Cat. No. Product Name Effect Purity
  • HY-75957
    DMP 777 Inhibitor 98.59%
    DMP 777 是一种有效的,选择性的,可口服的 leukocyte elastase 抑制剂。
  • HY-17443B
    Sivelestat sodium tetrahydrate Inhibitor >98.0%
    Sivelestat(ONO5046; LY544349; EI546)是人源白细胞弹性蛋白酶(neutrophil elastase)竞争性抑制剂,IC50值为44nM,亦能抑制鼠源,兔源等物种的白细胞弹性蛋白酶。
  • HY-15891
    GW311616 Inhibitor 99.30%
    GW311616是高活性,可渗透入细胞,口服生物相容性,长效的人中性白细胞弹性蛋白酶(HNE)抑制剂,IC50为22 nM,是GW311616A的游离碱形式。
  • HY-15651
    Alvelestat Inhibitor 99.27%
    Alvelestat (AZD9668)是新型口服人neutrophil elastase(NE)抑制剂,pIC50和Ki分别为7.9和4.9 nM。
  • HY-17443
    Sivelestat Inhibitor 98.54%
    Sivelestat(ONO5046; LY544349; EI546)是竞争性的人中性白细胞弹性蛋白酶抑制剂,IC50为44 nM,Ki为200 nM,还能抑制兔、鼠等的白细胞弹性蛋白酶。
  • HY-19908
    BAY-85-8501 Inhibitor
    BAY-85-8501 是人类中性脂酶 (HNE) 的一个有效的、选择性抑制剂,其 IC50 值为 65 pM。
  • HY-19254
    ZD-0892 Inhibitor
    ZD-0892是选择性和有效的中性粒细胞弹性蛋白酶 (neutrophil elastase) 抑制剂,对于人嗜中性粒细胞弹性蛋白酶和猪胰弹性蛋白酶的 Ki 值分别为6.7和200 nM。
  • HY-19406
    AE-3763 Inhibitor
    AE-3763 是基于多肽的人中性粒细胞弹性蛋白酶 (human neutrophil elastase) 抑制剂,IC50 值为29 nM。
  • HY-15891A
    GW311616 hydrochloride Inhibitor
    GW311616A(GW311616盐酸盐)是高活性,可渗透入细胞,口服生物相容性,长效的人中性白细胞弹性蛋白酶(HNE)抑制剂,IC50为22 nM。
  • HY-17443A
    Sivelestat sodium Inhibitor
    Sivelestat(ONO5046; LY544349; EI546)钠盐是人中性白细胞弹性蛋白酶(NE neutrophil elastase)竞争性抑制剂,IC50和Ki分别为44 nM和为200 nM,还能抑制来自于兔、鼠、仓鼠的白细胞弹性蛋白酶。
  • HY-100240
    Lodelaben Inhibitor
    Lodelaben 是一种人类嗜中性粒细胞弹性蛋白酶抑制剂,其 IC50Ki 值分别 0.5 和 1.5 μM。
  • HY-U00256
    ZD8321 Inhibitor
    ZD8321 是人 Neutrophil elastase (NE) 的有效抑制剂,其 Ki 值为 13±1.7 nM。
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