1. GPCR/G Protein
  2. GPCR19

GPCR19

GPCR19 (G-protein coupled receptor 19, GPBAR1) is a protein that in humans is encoded by the GPBAR1 gene. This gene encodes a member of the G protein-coupled receptor (GPCR) superfamily. GPCR19 functions as a cell surface receptor for bile acids. Treatment of cells expressing this GPCR with bile acids induces the production of intracellular cAMP, activation of a MAP kinase signaling pathway, and internalization of the receptor. The receptor is implicated in the suppression of macrophage functions and regulation of energy homeostasis by bile acids. One effect of this receptor is to activate deiodinases which convert the prohormone thyroxine (T4) to the active hormone triiodothyronine (T3). T3 in turn activates the thyroid hormone receptor which increases metabolic rate.

GPCR19 相关产品 (10):

Cat. No. Product Name Effect Purity
  • HY-15677
    INT-777 Agonist >98.0%
    INT-777是有效的 TGR5 激动剂,EC50 为 0.82 μM。
  • HY-12434
    INT-767 Agonist >98.0%
    INT-767是法尼醇X受体/TGR5双激动剂,平均 EC50 分别为30和630 nM。
  • HY-N0593
    Deoxycholic acid Activator >98.0%
    Deoxycholic acid 激活 G 蛋白偶联胆汁酸受体TGR5
  • HY-101274
    BAR501 Agonist 98.82%
    BAR501是高效选择性的GPBAR1激动剂,EC50值为1 μM.
  • HY-14229
    TGR5 Receptor Agonist Agonist 99.86%
    TGR5 Receptor Agonist是TGR5(GPCR19)激动剂。
  • HY-N0169
    Hyodeoxycholic acid Agonist
    Hyodeoxycholic acid 是有肠道菌群在小肠中形成的次级胆汁酸,为 TGR5 (GPCR19) 的激动剂,在 CHO 细胞中,EC50 值为 31.6 µM。
  • HY-N0593A
    Deoxycholic acid sodium salt Activator >98.0%
    Deoxycholic acid sodium salt 激活 G 蛋白偶联胆汁酸受体TGR5
  • HY-102016
    SB756050 Agonist 99.02%
    SB756050是选择性的 TGR5 激动剂,目前正处于临床一期实验用于治疗二型糖尿病。
  • HY-15677A
    INT-777 R-enantiomer Agonist
    INT-777 R-enantiomer 是 INT-77 的 R 型异构体,对 TGR5 的 EC50 值为 4.79 μM,活性比 INT-777 低。
  • HY-101273
    BAR502 Agonist >98.0%
    BAR502是FXRGPBAR1的双重激动剂,IC50值分别为2 μM 和0.4 μM
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