1. Apoptosis
  2. Apoptosis
    Caspase
  3. Taurodeoxychloic Acid sodium hydrate

Taurodeoxychloic Acid sodium hydrate (Synonyms: Sodium taurodeoxycholate monohydrate)

目录号: HY-B1899A
产品使用指南

Taurodeoxychloic Acid (sodium hydrate) 通过阻断钙介导的凋亡通路和 Caspase-12的活化来阻止细胞凋亡。Taurodeoxychloic Acid (sodium hydrate) 被用于多种研究,如原发性胆汁性肝硬化 (PBC),胰岛素抵抗,淀粉样变性,囊性纤维化,胆汁淤积和肌萎缩侧索硬化症。

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Taurodeoxychloic Acid sodium hydrate Chemical Structure

Taurodeoxychloic Acid sodium hydrate Chemical Structure

CAS No. : 110026-03-4

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Size Price Stock Quantity
10 mM * 1 mL in DMSO ¥550 In-stock
10 mg ¥500 In-stock
50 mg ¥1400 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Description

Taurodeoxychloic Acid (sodium hydrate) prevents apoptosis by blocking a calcium-mediated apoptotic pathway as well as caspase-12 activation. Taurodeoxychloic Acid (sodium hydrate) is investigated for use in several conditions such as Primary Biliary Cirrhosis (PBC), insulin resistance, amyloidosis, Cystic Fibrosis, Cholestasis, and Amyotrophic Lateral Sclerosis[1].

IC50 & Target

Caspase-12

 

In Vivo

Taurodeoxychloic Acid (TUDCA) is neuroprotective in a transgenic animal model of Huntington’s disease[2].

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (231.18 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8494 mL 9.2471 mL 18.4942 mL
5 mM 0.3699 mL 1.8494 mL 3.6988 mL
10 mM 0.1849 mL 0.9247 mL 1.8494 mL
* 请根据产品在不同溶剂中的溶解度,选择合适的溶剂配制储备液,并请注意储备液的保存方式和期限。
In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案,配制前请先配制澄清的储备液,再依次添加助溶剂 (为保证实验结果的可靠性,体内实验的工作
液,建议您现用现配,当天使用;澄清的储备液可以根据储存条件,适当保存;以下溶剂前的百分比是指该溶剂在您配制终溶液中的体积占比):

  • 1.

    请依序添加每种溶剂: 10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.85 mM); Clear solution

  • 2.

    请依序添加每种溶剂: 10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (3.85 mM); Clear solution

  • 3.

    请依序添加每种溶剂: 10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.85 mM); Clear solution

*以上所有助溶剂都可在 MCE 网站选购。
References
Molecular Weight

540.71

Formula

C₂₆H₄₇NNaO₇S+

CAS No.

110026-03-4

SMILES

C[C@H](CCC(NCCS(=O)(O)=O)=O)[C@H]1CC[C@@]2([H])[C@]3([H])CC[C@]4([H])C[C@H](O)CC[C@]4(C)[C@@]3([H])C[C@H](O)[C@]12C.[Na+].O

Shipping

Room temperature in continental US; may vary elsewhere

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

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产品名称:
Taurodeoxychloic Acid sodium hydrate
目录号:
HY-B1899A
需求量:

Taurodeoxychloic Acid sodium hydrate

Cat. No.: HY-B1899A