1. Stem Cell/Wnt
  2. β-catenin


β-catenin is a dual function protein, regulating the coordination of cell–cell adhesion and gene transcription. In humans, the CTNNB1 protein is encoded by the CTNNB1 gene. β-catenin is a subunit of the cadherin protein complex and acts as an intracellular signal transducer in the Wnt signaling pathway. It is a member of the catenin protein family and homologous to γ-catenin. Mutations and overexpression of β-catenin are associated with many cancers, including hepatocellular carcinoma, colorectal carcinoma, lung cancer,malignant breast tumors, ovarian and endometrial cancer. β-catenin is regulated and destroyed by the beta-catenin destruction complex, and in particular by the adenomatous polyposis coli (APC) protein, encoded by the tumour-suppressing APC gene. Therefore genetic mutation of the APC gene is also strongly linked to cancers, and in particular colorectal cancer resulting from familial adenomatous polyposis (FAP).

β-catenin 相关产品 (17):

Cat. No. Product Name Effect Purity
  • HY-15147
    XAV-939 Inhibitor 98.04%
    XAV-939 是一种具有选择性的 β-catenin -介导的转录抑制剂和轴蛋白的稳定剂,能够抑制 TNKS1 和 TNKS2 的活性,IC50 值分别为 5 和 2 nM。
  • HY-19940
    TD139 Inhibitor 99.39%
    TD139是半乳凝素-3 (galectin-3) 糖结合结构域的新型高亲和力抑制剂,其Kd值为14 nM。
  • HY-15597
    Salinomycin Inhibitor >98.0%
    Salinomycin 是一种 Wnt/β-catenin 通道抑制剂,作用于 Wnt/Fzd/LRP 复合体。Salinomycin强抑制 Wnt1刺激的报告基因活性,IC50 为 163 nM,且降低 β-catenin 水平。
  • HY-17577
    Berberine chloride hydrate Activator 99.56%
    Berberine chloride hydrate能有效的抑制多种癌细胞增殖,促进凋亡,能影响MAPK和Wnt/β-catenin通路。
  • HY-15721
    FH535 Inhibitor 99.93%
    FH535 是 Wnt/β-cateninPPAR 的抑制剂,具有抗肿瘤活性。
  • HY-101085
    SKL2001 Agonist 98.08%
    SKL2001 是 Wnt/β-catenin 信号通路的激动剂,具有抗肿瘤活性。
  • HY-101090
    KYA1797K Inhibitor >98.0%
    KYA1797K是有效,选择性的 Wnt/β-catenin 抑制剂,IC50 值为0.75 µM。
  • HY-11035
    WAY-262611 Agonist 99.08%
    WAY-262611是无翼的β-联蛋白激动剂,可增加骨形成速率,在TCF-荧光素酶测定实验中的EC50值为0.63 μM。
  • HY-101486
    LF3 Antagonist 98.58%
    LF3是β-Catenin/TCF4相互作用的拮抗剂,具有抗肿瘤活性。IC50值为1.65 μM。
  • HY-101130
    PNU-74654 Inhibitor 99.60%
    PNU-74654是Wnt/β-catenin通路的的抑制剂,在NCI-H295 细胞中的IC50值为129.8 μM。
  • HY-16910
    WIKI4 Inhibitor 99.77%
  • HY-B0012
    Pamidronic acid >98.0%
    Pamidronic acid 是用于治疗各种骨吸收类疾病的药物。
  • HY-102028
    KY1220 >98.0%
    KY1220作用于 Wnt/β-catenin 靶点,使β-catenin 和 Ras不稳定。在HEK293报告细胞中的IC50 值为2.1 μM。
  • HY-12319A
    Cardiogenol C hydrochloride Activator
    Cardiogenol C盐酸盐是一种细胞渗透性的嘧啶化合物, 有效诱导胚胎干细胞分化为心肌 (EC50= 100 nM)。
  • HY-B1057
    Nefopam hydrochloride Inhibitor 99.06%
    Nefopam是中枢性但非阿片类镇痛药, 缓解中度和重度疼痛。
  • HY-18258
    Berberine chloride Activator
  • HY-32736
    Triptonide Inhibitor 98.89%
    Triptonide(NSC 165677; PG 492)从雷公藤中提取,抑制由伴刀豆球蛋白A或脂多糖诱导的鼠脾细胞增殖。
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