1. Immunology/Inflammation
  2. IFNAR

IFNAR

The interferon-α/β receptor (IFNAR) is a receptor which binds type I interferons including interferon-α and -β. It is a heteromeric cell surface receptor composed of one chain with two subunits referred to as IFNAR1 and IFNAR2. Upon binding of type I IFNs, IFNAR activates the JAK-STAT signaling pathway. Interferon stimulation classically results in an anti-viral immune response. Type I IFNs share a common receptor consisting of two subunits, IFNAR1 and IFNAR2, which associate upon IFN binding. IFNAR2 is the major ligand binding component of the receptor complex, exhibiting nanomolar affinity to both IFNα and IFNβ subtypes. IFNAR1 and IFNAR2 belong to the class II helical cytokine receptor (hCR) family, which includes the receptor for type II IFN, tissue factor (TF), and IL10Rβ.

IFNAR 相关产品 (5):

Cat. No. Product Name Effect Purity
  • HY-100941
    CCCP Inhibitor 99.83%
    CCCP 通过破坏线粒体膜电位 (MMP) 来抑制 STING 介导的 IFN-β 产生。CCCP 且抑制 STING 及其下游信号分子 TBK1 和 IRF3 的激活。
  • HY-12836A
    IFN alpha-IFNAR-IN-1 hydrochloride Inhibitor 99.25%
    IFN alpha-IFNAR-IN-1盐酸盐是IFN alpha和其受体IFNAR相互作用抑制剂,EC50值2-8 μM。
  • HY-107390A
    AX-024 hydrochloride Inhibitor 99.29%
    AX-024 hydrochloride 是一种细胞因子释放抑制剂,可以有效抑制白细胞介素-6 (IL-6),肿瘤坏死因子-α (TNFα),干扰素-γ (IFN-γ),IL-10IL-17A 的产生。
  • HY-12836
    IFN alpha-IFNAR-IN-1 Inhibitor
    IFN alpha-IFNAR-IN-1是IFN alpha和其受体IFNAR相互作用抑制剂,EC50值2-8uM。
  • HY-107390
    AX-024 Inhibitor
    AX-024 是一种细胞因子释放抑制剂,可以有效抑制白细胞介素-6 (IL-6),肿瘤坏死因子-α (TNFα),干扰素-γ (IFN-γ),IL-10IL-17A 的产生。