1. Cell Cycle/DNA Damage
  2. IRE1


The serine/threonine-protein kinase/endoribonuclease inositol-requiring enzyme 1 (IRE1) is an enzyme that in humans is encoded by the ERN1 gene. IRE1 is an endoplasmic reticulum (ER) transmembrane sensor that activates UPR to maintain ER and cellular function. While mammalian IRE1 promotes cell survive, it can initiate apoptosis via decay of anti-apoptotic microRNAs.

IRE1 activation is initiated by homotypic interactions of the stress-sensing lumenal domain favoring transautophosphorylation of the kinase-extension nuclease (KEN) domain on the cytoplasmic side of the ER membrane.

IRE1/XBP-1 has been shown to regulate a variety of genes in various cell types in response to ER stress, mostly related to ER function and the secretory pathway, although the target genes vary depending on the cell type and nature of the stress stimuli.

IRE1 相关产品 (7):

Cat. No. Product Name Effect Purity
  • HY-15845
    STF-083010 Inhibitor >98.0%
    STF-083010 是一种 Ire1 抑制剂。STF-083010 抑制 Ire1 核酸内切酶活性,不影响激酶活性。
  • HY-17537
    APY29 Inhibitor 99.44%
    APY29 是一种特异性的 IRE1α 别构调节剂,能够抑制 IRE1α 的自主磷酸化,IC50 值为 280 nM。
  • HY-19707
    4μ8C Inhibitor 98.52%
    4μ8C (IRE1 Inhibitor III)是IRE1α的小分子抑制剂。
  • HY-19710
    MKC3946 Inhibitor 99.77%
    MKC3946 是一种有效的 IRE1α 抑制剂,常用于癌症研究。
  • HY-19708
    KIRA6 Inhibitor 98.75%
    KIRA6变构抑制IRE1α RNase激酶活性,IC50值为0.6 µM。
  • HY-12399
    MKC9989 Inhibitor 98.61%
    MKC9989 是一种 HAA 抑制剂,且能抑制 IRE1αIC50 值在 0.23 μM 至 44 μM 的范围之间。
  • HY-107371
    NSC95682 Inhibitor 99.87%
    NSC95682 是一个 IRE-1α 抑制剂,其 IC50 值为 0.08 μM,来自专利 WO 2008154484 A1, 实例 IRE-lα 抑制剂化合物 3-5。