1. Protein Tyrosine Kinase/RTK
  2. Insulin Receptor

Insulin Receptor

Insulin receptor (IR) is a transmembrane receptor that is activated by insulin, IGF-I, IGF-II and belongs to the large class of tyrosine kinase receptors. Metabolically, the insulin receptor plays a key role in the regulation of glucose homeostasis, a functional process that under degenerate conditions may result in a range of clinical manifestations including diabetes and cancer. Biochemically, the insulin receptor is encoded by a single gene INSR, from which alternate splicing during transcription results in either IR-A or IR-B isoforms. Downstream post-translational events of either isoform result in the formation of a proteolytically cleaved α and β subunit, which upon combination are ultimately capable of homo or hetero-dimerisation to produce the ≈320 kDa disulfide-linked transmembrane insulin receptor.

Insulin Receptor 相关产品 (12):

Cat. No. Product Name Effect Purity
  • HY-15656
    LDK378 Inhibitor 99.75%
    LDK378 是一种有效的特异性 ALK 抑制剂,IC50 为 0.2 nM。
  • HY-10191
    Linsitinib Inhibitor 99.69%
    Linsitinib 是一种选择性的 IGF-1R 抑制剂,IC50 值为 35 nM,也适度地作用于 InsRIC50 值为 75 nM;对 Abl,ALK,BTK,EGFR,FGFR1/2,PKA 等没有作用。
  • HY-50866
    NVP-AEW541 Inhibitor 98.76%
    NVP-AEW541 是一种有效的 IGF-1R 抑制剂,IC50 为 0.15 μM,也抑制 InsRIC50 为 0.14 μM。
  • HY-10200
    BMS-754807 Inhibitor 99.79%
    BMS-754807 是有效、可逆的胰岛素样生长因子1受体/胰岛素受体抑制剂,其 IC50 值分别为 1.8 和 1.7 nM,Ki 值均小于 2 nM;同时也抑制 Met,RON,TrkA,TrkB,AurA 和 AurB 的活性,其IC50 值分别为 6,44,7,4,9和 25 nM。
  • HY-100037
    NT157 Inhibitor 99.19%
    NT157是一种选择性的IRS-1/2抑制剂IC50 为 0.3 到0.8 μM。
  • HY-P0035
    Insulin(human)
    Insulin human 是由 51 个氨基酸组成的一种双链形式 (包含 A 链和 B 链) 的多肽激素,两条链间通过二硫键连接。
  • HY-P1156
    Insulin(cattle) 98.60%
    Insulin cattle 是牛胰脏中胰岛 B-细胞所分泌的一种调节糖代谢的蛋白质激素,是一种多肽。
  • HY-15656A
    LDK378 dihydrochloride Inhibitor 99.86%
    LDK378 2Hcl是ALK抑制剂,IC50为0.2 nM,比对IGF-1R和InsR的抑制性高40倍和35倍。
  • HY-10262
    BMS-536924 Inhibitor 98.73%
    BMS-536924是ATP竞争性IGF-1R/IR抑制剂, IC50分别为100 nM/73 nM。
  • HY-13020
    GSK1838705A Inhibitor 98.99%
    GSK1838705A是IGF-IR,InsR和ALK抑制剂,IC50分别为2.0,1.6和0.5 nM。
  • HY-100550
    MSDC 0160 >98.0%
    MSDC 0160是一种胰岛素增敏剂,同时也调节线粒体丙酮酸载体(MPC),后者控制细胞代谢,从而影响mTOR的活化。
  • HY-15481
    KU14R Antagonist
    KU14R是胰岛素受体拮抗剂,能选择性阻断由咪唑啉引起的胰岛素分泌。