1. Protein Tyrosine Kinase/RTK
  2. Insulin Receptor

Insulin Receptor

Insulin receptor (IR) is a transmembrane receptor that is activated by insulin, IGF-I, IGF-II and belongs to the large class of tyrosine kinase receptors. Metabolically, the insulin receptor plays a key role in the regulation of glucose homeostasis, a functional process that under degenerate conditions may result in a range of clinical manifestations including diabetes and cancer. Biochemically, the insulin receptor is encoded by a single gene INSR, from which alternate splicing during transcription results in either IR-A or IR-B isoforms. Downstream post-translational events of either isoform result in the formation of a proteolytically cleaved α and β subunit, which upon combination are ultimately capable of homo or hetero-dimerisation to produce the ≈320 kDa disulfide-linked transmembrane insulin receptor.

Insulin Receptor 相关产品 (15):

Cat. No. Product Name Effect Purity
  • HY-P0035
    Insulin(human)
    Insulin(human) 是一种多肽激素,其调节血液中的糖(葡萄糖)水平并且由胰岛的β细胞产生。
  • HY-10191
    Linsitinib Inhibitor 99.90%
    Losmapimod是 IGF-1胰岛素受体的双重抑制剂,IC50 分别为35 和 75 nM。
  • HY-15656
    LDK378 Inhibitor 99.95%
    LDK378是有效且特异性的 ALK 抑制剂,IC50 为 0.2 nM。
  • HY-P1156
    Insulin(cattle) 98.60%
    Insulin cattle 是牛胰脏中胰岛 B-细胞所分泌的一种调节糖代谢的蛋白质激素,是一种多肽。
  • HY-10200
    BMS-754807 Inhibitor 99.18%
    BMS-754807 是有效、可逆的胰岛素样生长因子1受体/胰岛素受体抑制剂,其 IC50 值分别为 1.8 和 1.7 nM,Ki 值均小于 2 nM;同时也抑制 Met,RON,TrkA,TrkB,AurA 和 AurB 的活性,其IC50 值分别为 6,44,7,4,9和 25 nM。
  • HY-112720
    AGL-2263 Inhibitor
    AGL-2263 是胰岛素受体 (IR) 的一个阻断剂。
  • HY-112819
    Insulin levels modulator Modulator
    Insulin levels modulator 可用于治疗糖尿病。
  • HY-50866
    NVP-AEW541 Inhibitor 98.76%
    NVP-AEW541 是一种有效的 IGF-1R 抑制剂,IC50 为 0.15 μM,也抑制 InsRIC50 为 0.14 μM。
  • HY-10262
    BMS-536924 Inhibitor 98.73%
    BMS-536924是ATP竞争性IGF-1R/IR抑制剂, IC50分别为100 nM/73 nM。
  • HY-100037
    NT157 Inhibitor 99.19%
    NT157是一种选择性的IRS-1/2抑制剂IC50 为 0.3 到0.8 μM。
  • HY-15656A
    LDK378 dihydrochloride Inhibitor 99.86%
    LDK378 2Hcl是ALK抑制剂,IC50为0.2 nM,比对IGF-1R和InsR的抑制性高40倍和35倍。
  • HY-13020
    GSK1838705A Inhibitor 98.99%
    GSK1838705A是高效,可逆的 IGF-IR 和胰岛素受体 (insulin receptor) 抑制剂,IC50 值分别为2.0 和 1.6 nM。也可抑制 ALKIC50 值为0.5 nM。
  • HY-100550
    MSDC 0160 >98.0%
    MSDC 0160是一种胰岛素增敏剂,同时也调节线粒体丙酮酸载体(MPC),后者控制细胞代谢,从而影响mTOR的活化。
  • HY-15481
    KU14R Antagonist
    KU14R是胰岛素受体拮抗剂,能选择性阻断由咪唑啉引起的胰岛素分泌。
  • HY-N0628
    Kaempferitrin Activator
    Kaempferitrin 是一种天然黄酮苷类化合物,具有镇痛、消炎、抗糖尿病、抗肿瘤和化疗的作用,同时可激活胰岛素 (insulin) 信号传导.
Isoform Specific Products

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.