1. Immunology/Inflammation
  2. NO Synthase

NO Synthase

Nitric oxide synthases (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO synthases catalyze the oxidation of L-arginine to NO and L-citrulline. Mammals contain three NOS isoforms: neuronal NOS (nNOS), inducible NOS (iNOS), and endothelial NOS (eNOS). NO produced from these different NOS isoforms is involved in a wide range of physiologic functions in the nervous, immune, and cardiovascular systems. Unregulated NO production can lead to pathologic conditions such as stroke, inflammation, and hypertension. Therefore, the control of NOS activity by isoform selective NOS inhibitors has great potential for therapeutic treatments of NO-related diseases.

NO Synthase 相关产品 (11):

Cat. No. Product Name Effect Purity
  • HY-18731
    1400W Dihydrochloride Inhibitor >98.0%
    1400W dihydrochloride是高效,选择性的诱导型一氧化氮合成酶 (NO synthase) 抑制剂,Ki 值为7 nM。
  • HY-N0455A
    L-Arginine hydrochloride Activator >98.0%
  • HY-12119
    GW274150 Inhibitor 99.84%
  • HY-19504
    AVE-3085 Activator
    AVE-3085 是一种有效的 nitric oxide synthase 增强剂,常用于治疗心血管疾病。
  • HY-N0455
    L-Arginine Activator
  • HY-101238
    Agmatine sulfate Inhibitor >98.0%
    Agmatine sulfate在多个靶点上发挥调节作用,如神经递质系统,离子通道,一氧化氮合成。它是 imidazoline receptor 的内源性激动剂和 NO synthase 抑制剂。
  • HY-B1581A
    L-Canavanine sulfate Inhibitor >98.0%
    L-Canavanine sulfate 是诱导型 NO 合酶 (NO synthase) 的选择性抑制剂。
  • HY-102015
    6-Biopterin 98.02%
    6-Biopterin (L-Biopterin),一种蝶呤衍生物,是一氧化氮合酶 (NO synthase) 辅因子。
  • HY-N2300
    Kuwanon A Inhibitor
    Kuwanon A是从桑树 (Morus alba L.) 的根皮中分离的的黄酮衍生物,抑制一氧化氮产生的IC50值为10.5 μM。
  • HY-12116
    L-NIL Inhibitor 99.26%
    L-NIL是有效和选择性的诱导型NO合成酶 (NO synthase) 抑制剂,对小鼠诱导型NO合成酶和大鼠脑组成型NO合成酶的 IC50 值分别为3.3 和 92 μM。
  • HY-B2141
    Bendazol Activator 99.45%
    Bendazol 是一种降压药物,也可以增强 NO 合成酶 (NO synthase) 在肾小球和集合小管中的活性。