1. Membrane Transporter/Ion Channel
  2. Na+/K+ ATPase

Na+/K+ ATPase

Na+/K+ ATPase (Sodium potassium pump) is a transmembrane protein complex found in all higher eukaryotes acting as a key energy-consuming pump maintaining ionic and osmotic balance in cells. Na+/K+ ATPase is an emerging cancer target that merits further investigation.

The constant activity of the Na+/K+-ATPase (NKA, or Na+ pump) is essential for re-establishing and maintaining this gradient. In cardiac and vascular smooth muscle the principal isoforms of the NKA are α1 and α2 and their physiological role is controlled both by their unique and independent signalling pathways, and their discrete subcellular distribution.

Na+/K+ ATPase 相关产品 (12):

Cat. No. Product Name Effect Purity
  • HY-B1049
    Digoxin Inhibitor 98.91%
    Digoxin 是一种强心苷,抑制钠钾ATP酶,有效抑制基孔肯雅病毒(CHIKV)感染。
  • HY-15718A
    Istaroxime hydrochloride Inhibitor 99.32%
    Istaroxime hydrochloride 是一种有效的 Na+,K+-ATPase 抑制剂,IC50 为 0.11 μM。
  • HY-B0542
    Ouabain Octahydrate Inhibitor 99.79%
    Ouabain Octahydrate 是 Na+/K+-ATPase 抑制剂,常用于治疗充血性心力衰竭。
  • HY-N0143
    Phlorizin Inhibitor
    Phlorizin 是一种非选择性的 SGLT 抑制剂,对于 hSGLT1hSGLT2Ki 值分别为 300 和 39 nM。Phlorizin 也是一个 Na+/K+-ATPase 抑制剂。
  • HY-B1357
    Digitoxin Inhibitor 98.23%
    Digitoxin是有效的 Na+/K+-ATPase抑制剂, EC50 值为0.78 μM。
  • HY-19556
    (+)-SJ733 Inhibitor 99.45%
    (+)-SJ733 是临床上治疗疟疾的候选物,也是一个 Na+-ATPase PfATP4 抑制剂。
  • HY-12283
    Rostafuroxin Antagonist
    Rostafuroxin(PST 2238)是一种抗高血压化合物Na+K ATPase拮抗剂;IC50为1.5 nM。
  • HY-B1429
    Chlorpropamide Inhibitor 98.73%
    Chlorpropamide是一种口服降糖剂, 用于治疗非胰岛素依赖型糖尿病 (NIDDM)。
  • HY-B1237
    Suloctidil Inhibitor 99.82%
    Suloctidil]是目前正在许多临床试验中评估的一种治疗痴呆和血栓形成病症的新药, Suloctidil作用于大鼠脑突触, 影响Na+/ K+ ATP酶活性和膜流动性。
  • HY-15718
    Istaroxime Inhibitor
    Istaroxime(PST-2744)能抑制钠/钾三磷酸腺苷酶(Na+/K+ ATPase),IC50为0.43μM。
  • HY-B0137A
    Prilocaine hydrochloride Inhibitor
  • HY-B0137
    Prilocaine Inhibitor